摘要
目的 :探讨调脂对急性冠状动脉 (冠脉 )综合征 (ACS)患者冠脉病变炎症的影响。方法 :采用随机、对照方法将 12 5例ACS患者 (在常规治疗下 )分为他汀治疗组 (6 3例 )和非他汀治疗组 (6 2例 ) ,另选健康对照者6 0例作为对照组。测定在治疗前、治疗后 8周血浆高敏C 反应蛋白 (HS CRP)、P 选择素、氧化修饰低密度脂蛋白 (ox LDL)、血清一氧化氮 (NO)水平的变化。结果 :①ACS患者的血浆HS CRP、P 选择素、ox LDL水平明显增高 ,血清NO水平明显降低 ,血浆HS CRP、P 选择素水平与ox LDL、血清NO水平有明显直线相关性。②他汀治疗组在治疗 8周后其血浆HS CRP、P 选择素与ox LDL水平明显下降 ,血清NO水平明显上升 ,非他汀治疗组各项指标无明显变化。结论 :他汀调脂可阻滞ACS患者冠脉病变的炎症反应。
Objective:To investigate the effects of lipid lowering therapy on inflammatory influence of coronary arteriosclerotic lesion in acute coronary syndrome (ACS). Methods:One hundred and twenty five patients ith ACS were treated by conventional therapy and randomly divided into simvastatin treating group (63 cases) and placebo group(62 cases), and 60 cases of heathy person were selected as control group. The levels of plasma high sensitive C reactive protein (HS CRP), P selectin , oxidized low density lipoprotein (ox LDL) and serum nitric oxide (NO) were measured in before and after treatment with Simvastatin(20 mg/d) or placebo for 8 weeks. Results:① Patients with ACS had higher levels of plasma HS CRP, P selectin and ox LDL, and lower level of serum NO. There were correlated between levels of plasma HS CRP, P selectin and ox LDL or serum NO. ② The patients with ACS in simvastatin group has significantly reduced plasma HS CRP, P selectin and ox LDL levels and significantly elevated serum NO level, But the placebo group had no change.Conclusion:The inflammation of coronary arteriosclerotic lesion with ACS can be blocked by simvastatin.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2003年第2期90-92,共3页
Journal of Clinical Cardiology
