摘要
目的 :探讨 Ki6 7基因在鼻咽癌的表达及其与鼻咽癌远处转移、临床分期等的关系。方法 :应用免疫组化法对 6 6例鼻咽癌标本 Ki6 7基因表达情况进行检测 ,其中 33例有远处转移 ,33例无远处转移。 4 6例有颈淋巴结转移 ,2 0例无颈淋巴结转移。结果 :1有远处转移组的鼻咽癌组织 ,Ki6 7表达水平明显高于无远处转移组 (P<0 .0 0 1) ;2 Ki6 7的表达与临床分期呈正相关 (r =0 .2 6 8,P <0 .0 5 ) ;3Ki6 7的表达与 T分期无明显关系 ;4有淋巴结转移的病例其 Ki6 7的表达高于无淋巴结转移组 ,但差异无统计学意义 (P >0 .0 5 )。结论 :Ki6 7表达的增高可能与鼻咽癌远处转移有关 ;Ki6 7表达的高低可能与鼻咽癌的临床分期有关 ,Ki6
Objective:To evaluate the significance of Ki67 protein expression in Nasopharyngeal carcinoma(NPC), and the relationship between Ki67 and distance metastasis, Ki67 and clinical stage,et al.Methods:Immunohistochemical technique was applied to detect Ki67 protein which correlated in cell proliferation expression in 66 NPC patients .Of at the cases, 33 had distant metastases and another 33 had not distant metastases; one case was classified at clinical stage Ⅰ; 18 cases were classified at clinical stageⅡ, 31 cases were classified at clinical stage Ⅲ, 16 cases were classified at clinical stage Ⅳ; and 46 cases had cervical lymph nodes metastases and another 20 cases didn't. Results:①The expression of Ki67 in the group with distant metastases was significantly higher than that in the group without distant metastases (P<0.001); ②The correlation between Ki67 and clinical stage was positive (r=0.268,P<0.05);③the expression of Ki67 was not related to T stage;④the expression of Ki67 in the cases with cervical lymph nodes metastasis was higher than that of those without . However, there was no statistically significant correlation existing between both groups(P>0.05).Conclusions:The increased expression of the Ki67 gene could be correlated to the carcinoma distant metastasis in NPC patients. Alteration of Ki67 protein expression in the tissues of NPC may be related to the clinical stage of NPC,the expression of Ki67 may be used as an indicator for evaluating prognosis of NPC.
出处
《广西医科大学学报》
CAS
2002年第6期787-789,共3页
Journal of Guangxi Medical University
关键词
KI67基因
鼻咽癌
免疫组织化学
远处转移
Ki67 gene
nasopharyngeal carcinoma
immunohistochemistry
distant metastasis
