期刊文献+

培美曲塞联合顺铂治疗非小细胞肺癌临床观察 被引量:3

下载PDF
导出
摘要 目的 观察培美曲塞联合顺铂作用于非小细胞肺癌的临床疗效。方法 选择2014年4月到2015年6月期间在我院进行治疗的72例非小细胞肺癌患者为研究对象,将其随机分为观察组和对照组,各36例,对照组予以多西他赛联合顺铂化疗,观察组予以培美曲塞联合顺铂化疗,对比2组临床治疗效果。结果 化疗6个疗程后,观察组总有效率75.0%,优于对照组41.7%,对比2组临床疗效,差异具有高度统计学意义(χ~2=15.34,P<0.01)。结论 对非小细胞肺癌患者施以培美曲塞联合顺铂治疗的效果显著,值得临床推广应用。
作者 张园 张卿
出处 《解放军预防医学杂志》 CAS 2016年第S1期162-163,共2页 Journal of Preventive Medicine of Chinese People's Liberation Army
  • 相关文献

参考文献5

二级参考文献62

  • 1孙永臣,刘军,杨曦,韩文杰.培美曲塞二线治疗晚期非小细胞肺癌的临床对比研究[J].中国临床实用医学,2014,0(6):54-55. 被引量:3
  • 2Sun,Y,Wu,Y.-L,Zhou,C,et al.Second-line pemetrexed versus docetaxel in Chinese patients with locally advanced or metastatic non-small cell lung cancer:A randomized,open-label study[J].Lung cancer,2013,79(2):143.
  • 3Kim,Y.H.,Hirabayashi,M.,Togashi,Y.et al.Phase II study of carboplatin and pemetrexed in advanced non-squamous,non-small-cell lung cancer:Kyoto thoracic oncology research group trial 0902[J].Cancer Chemotherapy and Pharmacology,2012,70(2):271.
  • 4Li,B.-S.,Gong,H.-Y.,Huang,W.et al.Phase I study of pemetrexed,cisplatin,and concurrent radiotherapy in patients with locally advanced non-small cell lung cancer[J].American Journal of Clinical Oncology,2012,35(2):115.
  • 5Behera M,Owonikoko T K.,Chen Z,et al.Single agent maintenance therapy for advanced stage non-small cell lung cancer:A meta-analysis[J].Lung cancer,2012,77(2):331.
  • 6Scagliotti G V,Parikh P,von Pawel J,et al.PhaseⅢstudy comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced stage non-small cell lung cancer[J].J Clin Oncol,2008,26(21):3543-3551.
  • 7Jones R J,Twelves C J.Pemetrexed:a multitargeted antifolate(ALIMTA,LY-231514)[J].Expert Rev Anticancer Ther,2002,2(1):13-22.
  • 8Delbaldo C,Michiels S,Syz N,et al.Benefits of adding a drug to a single-agent or a 2-agent chemotherapy regimen in advanced nonsmall-cell lung cancer:a meta-analysis[J].JAMA,2004,292(4):470-484.
  • 9Yang C H,Simms L,Park K,et al.Efficacy and safety of cisplatin/pe-metrexed versus cisplatin/gemcitabine as first-line treatment in east asian patients with advanced non-small cell lung cancer:results of anexploratory subgroup analysis of a phase III trial[J].J Thorac Oncol,2010,5(5):688-695.
  • 10Filleron T,Md F D,Kramar A,et al.Prognostic factors fo young women(≤35 years)with node positive breast cancer:possible influence on post-therapeutic follow-up[J].Bull Cancer,2013,100(7/8):22-29.

共引文献41

同被引文献19

引证文献3

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部