摘要
目的 :探讨大豆皂甙对免疫抑制剂所致免疫损伤的保护作用。方法 :利用已知具有免疫毒性的物质环磷酰胺制造小鼠免疫损伤模型 ,同时给予不同剂量的大豆皂甙 ,从免疫器官、细胞免疫、体液免疫和非特异性免疫等方面观察了大豆皂甙对环磷酰胺所致小鼠免疫失衡的保护作用。结果 :在 2 0mg kg剂量条件下 ,环磷酰胺对受试小鼠具有明显的免疫抑制作用 ,它不仅可以引起受试小鼠免疫器官发生功能改变或萎缩 ,而且还使受试小鼠的体液免疫和细胞免疫受到抑制。但在给予环磷酰胺的同时投予大豆皂甙 ,在 10mg kg ,2 0mg kg和 30mg kg剂量范围下 ,大豆皂甙可以不同程度地拮抗环磷酰胺所致小鼠的免疫损伤 ,对接触环磷酰胺小鼠的免疫器官及体液免疫和细胞功能均具有保护作用。结论
Objective:To investigate the immunoregulation effects of soya saponin.Methods:The immune damage model of the mice was made by administration of cyclophosphamide,which was known as the immune toxicant. Meanwhile, the different dosages of soya saponin was given to the mice. The protecting effects of soya saponin were observed from different aspects of immune organs, cellular immunity, humoral immunity and nonspecific immunity.Results:The cyclophosphamide had a significant immunosuppressive effect at the dosage of 20?mg/kg. Such dosage of cyclophosphamide could not only change the function of mouse immune organs and made them atrophic,but also could suppress the function of mouse cellular immunity and humoral immunity. If the soya saponin was applied together with cyclophosphamide(10?mg/kg, 20?mg/kg and 30?mg/kg),it could antagonize the damaging effect of cyclophospha_mide on immune system.The soya saponin could protect the immune organs, the cellular immunity and humoral immunity. Conclusion:Soya saponin has protective effect on the mice with immune unbalance.
出处
《军事医学科学院院刊》
CAS
CSCD
北大核心
2003年第1期44-46,共3页
Bulletin of the Academy of Military Medical Sciences
关键词
大豆皂甙
环磷酰胺
免疫抑制剂
免疫毒素类
小鼠
免疫失衡
保护
soya saponin
cyclophosphamide
immunosuppressant agents
immunotoxips
mice
immune unbalance
protection
