摘要
目的 观察血浆置换、血浆灌流两种典型非生物型人工肝对重肝衰竭患者体内血浆内毒素及细胞因子的清除效果。方法 7例和 10例重型肝炎患者分别行血浆灌流、血浆置换治疗 ,比较治疗前后患者血液中内毒素、细胞因子等的变化。结果 经血浆灌流治疗后 ,患者血中细胞因子、内毒素显著下降 ,但IL 6变化不大 ;血浆置换治疗后 ,患者血中内毒素下降明显 ,但对TNF α、IL 1β、IL 6清除效果欠佳。 结论 血浆灌流能更有效清除血浆多数细胞因子、内毒素 ,有望成为有效清除细胞因子的一种治疗手段 。
Objective To evaluate the abilities of plasma perfusion and plasma exchange to remove blood endotoxin and cytokines from hepatic failure patients. Methods Plasma perfusion and plasma exchange were performed on 7 cases and 10 cases for the treatment of chronic severe hepatitis, respectively. Changes of blood endotoxin and cytokines before and after treatment were analyzed. Results The levels of cytokines and endotoxin in patient blood decreased greatly, but bilirubin decreased slightly after treatment with plasma perfusion. The changes of interleukin 6 were very limited. Compared with plasma perfusion, the removal of bilirubin was higher but that of cytokines was lower after plasma exchange. Conclusion Plasma perfusion can remove cytokines with high efficiency and retard the development of hepatic failure.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2003年第6期487-488,共2页
Journal of Third Military Medical University
基金
国家自然科学基金资助项目 ( 30 0 2 70 0 1)
关键词
肝衰竭
血浆灌流
血浆置换
内毒素
细胞因子
hepatic failure
plasma perfusion
plasma exchange
endotoxin
cytokine
