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CD44v6和P16蛋白表达与大肠癌浸润和转移的关系 被引量:4

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摘要 目的 探讨CD44v6和P16蛋白表达与大肠癌浸润转移的相关性。方法 应用免疫组织化学技术,检测90例大肠癌组织中CD44v6和P16蛋白表达。结果 90例大肠癌中CD44v6和P16蛋白阳性表达分别为68例(75.6%)和46例(51.1%)。CD44v6高表达及P16蛋白低表达与大肠癌Dukes分期,浆膜浸润,淋巴结转移和肝脏转移均呈正相关(P<0.05)。大肠癌中CD44v6表达与P16蛋白表达呈负相关(r=-0.52,P<0.005)。结论 CD44v6和P16蛋白表达与大肠癌浸润转移密切相关。检测两者基因产物表达均可作为预测大肠癌侵袭转移的客观指标。
出处 《世界肿瘤杂志》 2003年第1期35-37,共3页 Tumour Journal of the World
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