摘要
目的 :观察雷米普利与螺内酯联合治疗充血性心力衰竭 (CHF)患者的心功能、心率、心胸比率 ,左室射血分数 (LVEF)指标的变化情况。方法 :将 6 4例CHF患者随机分为二组 ,均给予地高辛与利尿剂治疗 ,治疗组加雷米普利、螺内酯治疗 12周。结果 :两组治疗 1周后 ,心率减慢与治疗前相比有显著差异 (P <0 .0 1) ;治疗组治疗 12周与治疗 1周相比心率减慢仍有显著差异(P <0 .0 1) ,而对照组则改善不明显 (P >0 .0 5) ,治疗组治疗 12周后心胸比率缩小 ,LVEF提高较治疗前有非常显著差异 (P <0 .0 1) ,而对照组则无明显差异 (P >0 .0 5)。结论 :雷米普利与螺内酯联合治疗CHF疗效满意且较安全。
Objective:To observe the changes of the patients with congestive heart failure(CHF) in heart function,heart rate,cardial chest ratio and left ventricular ejection fraction (LVEF) after treatment with ramipril and antisterone.Methods:64 patients with CHF were randomly divided into therapy group and control group.Diuretic and digoxin were given to the patients in both groups.Ramipril and antisterone were given to the patients in therapy group,for 12 weeks.Results:After one week,the heart rate was declined obviously in therapy group than that in control group.There were significant differences between two groups(P<0.01).In therapy group,the heart rate still decreased significantly after twelve weeks than after one week,but it was not obvious changes in control group(P>0.05).In therapy group,the cardia/chest ratio and LVEF were improved abviously after twelve weeks than before treatment,but there were not significant differences in control group (P>0.05).Conclusion:The effect of ramipril and antisterone in the treatment of CHF was satisfactory and safe.
出处
《右江医学》
2003年第1期10-11,共2页
Chinese Youjiang Medical Journal
