摘要
目的:探讨环氧化酶-2(COX-2)和p53在胰腺癌组织中的表达与生物学行为之间的关系并探讨二者的相关性及可能机制.方法:用免疫组织化学Envision法对51例胰腺导管癌和11例癌旁非肿瘤胰腺组织的COX-2和p53的表达进行检测.结果:51例胰腺导管癌中COX-2和p53蛋白的表达率分别为74.5%和60.8%;二者在11例癌旁非肿瘤胰腺组织中均未发现阳性表达.COX-2的表达与临床分期和淋巴结转移有关(P=0.022,0.036),而与组织学分级关系不大(P=0.152);p53的表达与淋巴结转移有关(P=0.035),而与组织学分级、临床分期关系不大(P=0.131,0.078);COX-2的表达与p53的表达密切相关(r=0.452,P=0.001).二者的表达与患者的性别、年龄、肿瘤的大小、部位均无关.结论:COX-2和p53的协同作用可能在胰腺癌的发生发展过程中起重要作用,可能为胰腺癌的治疗提供了新的靶点.
AIM:To investigate the expressions of COX-2 and p53 in human pancreatic cancer and their correlation with biological behaviors of pancreatic cancer. METHODS:The expressions of COX-2 and p53 in 51 specimens of human pancreatic ductal adenocarcinoma and 11 specimens of normal tissues adjacent human pancreatic ductal adenocarci- noma were detected with immunohistochemistry by Envision. RESULTS:The detectable rate of COX-2 and p53 in pancreatic ductal adenocarcinoma were 74.5 % and 60.8 %, respectively; but none in adjacent normal tissues. The expression of COX-2 was significantly associated with the clinical stages and me- tastasis status of lymph nodes (P =0.022, 0.036) , but not with histological grade (P =0.152). The expression of p53 was significantly correlated with the lymph node metastasis status (P =0.035) , but not with their histological grades and clinical stages (P =0.131, 0.078). There was a significant correlation between the expression of COX-2 and p53 (r =0. 452, P =0.001).Conditions such as age, sex, tumor size and location had no relation with expression of COX-2 or p53. CONCLUSION:The cooperation of COX-2 and p53 may play a pivotal role in the carcinogenesis and the progression in pancreatic cancer. They may provide new targets for the therapy of pancreatic cancer.
出处
《世界华人消化杂志》
CAS
2003年第2期229-232,共4页
World Chinese Journal of Digestology
