摘要
为探讨健脾补肾利湿方对去卵巢 (OVX)大鼠晚期糖化终末产物 (AGEs)和过氧化物的影响。雌性SD大鼠去除双侧卵巢 2周后健脾补肾利湿方治疗 13周。结果表明 ,与假手术组相比 ,去卵巢组主动脉AGEs、甘油三脂 (TG)、氧化低密度脂蛋白(OX LDL)和丙二醛 (MDA)均明显升高 ;高密度脂蛋白 -胆固醇 (HDL C)、载脂蛋白AⅠ (apo AⅠ )和超氧化物歧化酶 (SOD)活性均显著降低。健脾补肾利湿方治疗组大鼠主动脉AGEs、血清TG、MDA和OX LDL均明显低于去卵巢组 ;HDL C、apo AⅠ和SOD活性均显著升高。提示健脾补肾利湿方通过降低去卵巢大鼠主动脉AGEs含量 ,降低大鼠血清OX LDL和MDA含量 ,升高血清SOD活性 ,调节血脂 ,发挥其对心血管的保护作用。
To investigate effects of Jian Pi Bu Shen Li Shi Recipe (JBLF) on advanced glycosylation end products (AGEs) and serum lipid peroxide of ovariectomized rats. A total of 29 rats were randomly divided into sham group(sham), ovariectomized group(OVX) and OVX+JBLF group. JBLF was given to the OVX+ JBLF group 2 weeks after ovariectomy. Levels of aortic AGEs and serum lipid peroxide were detected after 13 weeks of treatment. The aortic AGEs, serum triglycerides(TG), oxidated LDL(OX LDL) and malondialdehyde(MDA) of the OVX group were higher(P<0.01,P<0.05, P<0.05 and P<0.01 respectively) and the levels of high density lipoprotein-cholesterol(HDL C), apolipoproptein AⅠ(apo AⅠ) and activity of peroxide dismutase(SOD) were lower ( P<0.01,all) than that of the sham group.JBLF not only reduced the concentration of aortic AGEs,Serum OX LDL and TG (P<0.01, P<0.05 and P<0.05 respectively) but also increased concentration of serum HDL C, apo AⅠand SOD activity(P<0.05, P<0.01 and P<0.01 respectively). The study suggested that JBLF could decrease aortic AGEs, OX LDL and serum MDA, enhance serum SOD activity, therefore it maybe helpful in cardiovascular system.
出处
《中药药理与临床》
CAS
CSCD
2003年第1期24-26,共3页
Pharmacology and Clinics of Chinese Materia Medica
