摘要
目的 :观察通心络胶囊对急性脑梗死的治疗效果以及对患者凝血 -纤溶指标的影响 ,以综合分析其作用机理。方法 :将 6 4例急性脑梗死患者随机分为两组 ,通心络胶囊加常规药物治疗组 (治疗组 ) 33例 ,对照组 31例。观察两组患者治疗后有效率 ,治疗前后神经功能缺损评分、组织型纤溶酶原激活剂 (tPA)、纤溶酶原激活物抑制剂 (PAI)、抗凝血酶 Ⅲ (AT Ⅲ )、血栓素B2 (TXB2 )及 6 -酮 -前列腺素F1α(6 keto PGF1α)的变化。结果 :治疗组总有效率为 84 8%、平均减少积分为 (9 33± 4 4 7)分 ,明显优于对照组的 71 0 %、(8 5 0± 4 6 0 )分 (P <0 0 5 ) ;在升高血浆AT Ⅲ含量、降低TXB2 、升高TXB2 / 6 keto PGF1α比值方面与对照组比较 ,差异有显著性 (P <0 0 5 )。结论 :通心络胶囊作为急性脑梗死联合用药 ,可明显提高临床疗效 ;其作用机制可能与其抗凝及抑制血小板活化有关。
Objective: To explore the acting mechanism of Tongxinluo Capsule (TXLC) by observing its therapeutic effect in treating acute cerebral infarction and the effect on parameters of blood fibrinolysis. Methods: Sixty four patients with acute cerebral infarction were randomly divided into the TXLC group (n=33) and the control group (n=31). The therapeutic effect and changes of neurofunction deficit score, tissue type plasminogen activator (tPA), plasminogen activator inhibitor (PAI), antithrombin Ⅲ (AT Ⅲ), thromboxane B 2 (TXB 2), 6 keto PGF 1α before and after treatment in the two groups were observed. Results: The effective rate (84.8%) and the average decreased score (9.33±4.47) in the TXLC group were obviously better than those in the control group. Significant difference was also found between the two groups in increase of AT Ⅲ plasma content, decrease of TXB 2 level and increase of TXB 2/6 keto PGF 1α ratio (P<0 05). Conclusion: As an combined treatment of acute cerebral infarction, TXLC could markedly improve the therapeutic effect of conventional treatment, the mechanism could be related mainly to its effects of anti coagulation and anti platelet activation.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2003年第2期94-96,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
中西医结合治疗
通心络胶囊
急性脑梗死
Tongxinluo Capsule, acute cerebral infarction, tissue type plasminogen activator, plasminogen activator inhibitor, antithrombin Ⅲ, thromboxane B 2, 6 keto PGF 1α
