摘要
目的研究载脂蛋白E基因多态性与女性冠心病发病的关系。方法以载脂蛋白E(ApoE)、女性冠心病、基因多态性、Apolipoprotein E、women coronary heart disease、gene polymorphisms为检索词,检索万方数据库、中国知网、中国生物医学文献、SpringerLink数据库和PubMed数据库,检索时时限为建库至2018年9月30日。然后以等位基因E2、E4分别与E3相比较,基因型E2/2、E2/3、E2/4、E3/4、E4/4分别与E3/3相比较。应用统计学软件Stata14.0对所有数据进行Meta分析,计数资料采用合并比值比(OR值)和95%可信区间(95%CI)描述。异质性分析过程应用I^2完成,认为P<0.1或I^2>50%时存在明显的异质性。发表偏倚用漏斗图进行分析。结果的可靠性通过敏感性分析评估。P<0.05为差异有统计学意义。结果初步检索文献940篇,最终纳入9篇。其中中文1篇,英文8篇。所选文献均使用NOS质量评分量表进行质量评价,所选文献均大于5分,为高质量文献。所选文献Meta分析结果示基因型E2/2[OR 4.65,95%CI (1.02,21.19)]、E3/4[OR 1.68,95%CI (1.00,2.82)]、E4/4[OR 4.55,95%CI (2.16,9.60)]在病例组表达率要显著高于对照组,E2/3[OR 1.10,95%CI (0.79,1.54)]、E2/4[OR 1.03,95%CI (0.51,2.07)]与女性冠心病的发病无统计学意义。结论 E2/2、E3/4、E4/4基因携带者女性冠心病的发病风险显著增加;E2/3、E2/4携带者无明确相关性。
Aim To study the relationship between apolipoprotein E gene polymorphism and coronary heart disease in women.Methods Apolipoprotein E,female coronary heart disease,and gene polymorphism were used as the search terms,and Wanfang,CNKI,Chinese biomedical literature,SpringerLink database and PubMed database were searched from foundation September 30,2018.Alleles E2 and E4 were compared with E3,and genotypes E2/2,E2/3,E2/4,E3/4 and E4/4 were compared with E3/3,respectively.Statistical software Stata14.0 was used for Meta analysis of all data,and combined odds ratio(OR value)and 95%confidence interval(95%CI)were used to describe the counting data.The heterogeneity analysis process was completed with I^2,and it was considered that there was significant heterogeneity when P<0.1 or I^2>50%.Publication bias was analyzed using funnel plot.The reliability of the results was assessed by sensitivity analysis.P<0.05 was considered statistically significant.Results A total of 940 related literatures were retrieved,and 9 literatures were finally included.One in Chinese and eight in English.The selected literatures were all case-control studies,and the literatures were evaluated by NOS quality score scale.The selected literatures were all higher than 5 points,which was considered as high-quality literatures.Meta analysis results of selected literature showed that genotype E2/2(OR 4.65,95%CI(1.02,21.19)),E3/4(OR 1.68,95%CI(1.00,2.82)),E4/4(OR 4.55,95%CI(2.16,9.60))were significantly higher in the case group than in the control group,E2/3(OR 1.10,95%CI(0.79,1.54)),E2/4(OR 1.03,95%CI(0.51,2.07))had no statistical significance in the incidence of female coronary heart disease.Conclusion The risk of coronary heart disease increased significantly in women with the genotype E2/2,E3/4 and E4/4.
作者
李晓轩
边云飞
邱龄
李嘉伟
刘真成
张婉丽
LI Xiaoxuan;BIAN Yunfei;QIU Ling;LI Jiawei;LIU Zhencheng;ZHANG Wanli(Shanxi Medical University,Taiyuan,Shanxi030000,China;Department of Cardiology,the Second Hospital of ShanxiMedical University,Taiyuan,Shanxi030000,China)
出处
《中国动脉硬化杂志》
CAS
2019年第10期893-898,共6页
Chinese Journal of Arteriosclerosis
关键词
载脂蛋白E
女性冠心病
基因多态性
apolipoprotein E
female coronary heart disease
gene polymorphism
