摘要
苦参碱已被广泛应用于病毒性肝炎的治疗。苦参碱治疗病毒性肝炎的疗效优于苦黄注射液、茵栀黄注射液,优于或稍优于甘草酸二铵,与干扰素、拉米夫定、阿德福韦酯相当。苦参碱还可以减少干扰素、甘草酸二铵的不良反应发生。熊去氧胆酸、腺苷蛋氨酸能增强苦参碱治疗病毒性肝炎的疗效。苦参碱对病毒性肝炎的总胆红素复常率高于苦黄注射液、茵栀黄注射液、甘草酸二铵,这可能与苦参碱还具有促进胆汁分泌有关。综述苦参碱对病毒性肝炎的临床疗效文献,并对其研究进展做了分析。
Matrine has been used extensively for the treatment of viral hepatitis. Clinical efficacy of matrine on viral hepatitis is better than Kuhuang Injection and Yinzhihuang Injection;better than or slightly better than diammonium glycyrrhizinate, corresponding to interferon, lamivudine and adefovir dipivoxil. Matrine may decrease the occurrences of adverse effects of interferon or diammonium glycyrrhizinate. Ursodeoxycholate or adenosylmethionine may increase clinical efficacy of matrine for treatment of viral hepatitis. Recovery rate of TBil of matrine is higher than Kuhuang Injection, Yinzhihuang Injection, diammonium glycyrrhizinate;this may be relative to accelerating biliation of matrine.The literatures of clinical efficacy of matrine in viral hepatitis are reviewed and its research progress is analyzed.
作者
张明发
沈雅琴
ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204,China)
出处
《抗感染药学》
2019年第1期5-9,共5页
Anti-infection Pharmacy
