摘要
从诱导脊椎动物早期胚胎的中胚层到器官和组织的形成 ,成纤维细胞生长因子家族(FGFs)在其各个阶段起着重要的作用。FGFs在各种器官形成中担负上皮 间质相互作用的重要调控因子 ,特别是FGF1 0 ,无论在外胚层上皮还是在内皮层上皮都是重要的间质调控因子。如果离开该因子 ,胚胎组织 器官发生将无法完成。就FGF1 0调控四肢、支气管 -肺脏、胰腺、脑垂体、皮肤、牙齿、下颌下腺和白色脂肪等组织器官形态发生的最新研究进展进行综述。
Fibrobalast growth factors(FGFs) are members of a family of polypeptide mitogens eliciting a wide variety of responses including induction mesoderm developing into tissue and organ.These proteins,especial FGF10,play crucial roles in various organ formation as important regulators influencing the interaction of epithelia and mesenchyma.The knowledge of FGF10 regulating the development of tissue/organ at embryonic stage has recently expanded remarkably.In this article,the lastest achievements in FGF10 regulating the morphogenesis of limbs,bronchio-lung,pancreas,hypophysis,skin,teeth,submandibular gland and whit fat were reviewed.;
出处
《中国生物工程杂志》
CAS
CSCD
2003年第3期25-29,共5页
China Biotechnology
基金
国家自然科学基金资助项目 ( 30 2 30 370 )
