摘要
目的:分析C反应蛋白(CRP)、尿脱氧吡啶啉(UDPd)/肌酐含量(Scr)等炎性指标与口腔种植修复患者的相关性。方法:选取于我院接受口腔种植修复的患者60例作为观察组,同时选择60例体检健康的成人作为对照组。比较两组研究对象的血清C反应蛋白(CRP)、尿脱氧吡啶啉(UDPd)/肌酐含量(Scr)、白细胞介素-1 (IL-1)、白细胞介素6 (IL-6)和肿瘤坏死因子α。结果:观察组术后1周及术后1个月的血清CRP、IL-1、IL-6、TNF-α水平及UDPd/Scr均显著高于对照组(P<0.05);Pearson相关性分析表明,观察组术后1个月CRP水平与UDPd/Scr比值呈正相关(r=0.301,P=0.004);根据X射线检查结果将患者分为整合不良组(n=8)和整合良好组(n=52),整合良好组患者的CRP、UDPd/Scr比值、IL-1、IL-6、TNF-α水平均明显低于整合不良组(P<0.05)。结论:在口腔修复过程中,血清CRP、尿液UDPd/Scr比值会显著升高,且两者之间呈正相关;CRP、UDPd/Scr等炎性指标口腔种植修复患者的预后相关。
To analyze the correlation between C-reactive protein(CRP),urinary deoxypyridine(UDPd)/creatinine content(Scr)and inflammatory indicators in patients with oral implantation.Methods:60 patients who received oral implantation in our hospital were selected as the observation group,and 60 healthy adults were selected as the control group.Serum C reactive protein(CRP),urinary deoxypyridine(UDPd)/creatinine(Sce),interleukin-1(IL-1),interleukin 6(IL-6)and tumor necrosis factor were compared between the two groups.Results:Serum CRP,IL-1,IL-6,TNF-levels and UDPd/Scr in the observation group were significantly higher than those in the control group 1 week and 1 month after surgery(P<0.05),Pearson correlation analysis showed that CRP level in the observation group was positively correlated with UDPd/Scr ratio 1 month after surgery(r=0.301,P=0.004).According to the Xray examination results,the patients were divided into the poorly integrated group(n=8)and the wellintegrated group(n=52).The CRP,UDPd/Scr ratio and IL-1,IL-6 and TNF-levels in the well-integrated group were significantly lower than those in the poorly integrated group(P<0.05).Conclusion:In the process of oral repair,serum CRP and urine UDPd/Scr ratio will be significantly increased and there is a positive correlation between the two.CRP,UDPd/Scr and other inflammatory indicators are correlated with the prognosis of patients with oral implantation and restoration.
作者
吴剑波
殷丽
耿发云
李红文
WU Jianbo;YIN Li;GENG Fayun(Department of Stomatology,Otolaryngology Hospital,Longgang District,Shenzhen 518172,Guangdong Province,China)
出处
《中国口腔种植学杂志》
2019年第1期22-24,共3页
Chinese Journal of Oral Implantology
关键词
C反应蛋白
尿脱氧吡啶啉
肌酐
口腔种植修复术
C-reactive protein
urinary deoxypyridine
creatinine
dental implant repair
