摘要
目的 :通过 4 0例喉鳞癌患者血清一氧化氮 (NO)浓度的测定 ,研究一氧化氮在喉鳞癌中的表达及其临床意义 ,探讨一氧化氮在喉癌肿瘤免疫方面的作用。方法 :采用硝酸还原酶法测定健康人和喉癌患者血清NO-3 和NO-2 之和反应体内一氧化氮水平。检测了 4 0例不同临床分期的喉鳞癌患者及 30例健康体检者。结果 :喉鳞癌患者血清一氧化氮含量显著高于健康人 ,前者为 (12 2 4 5± 4 1 2 3) μmol/L ,后者仅为 (6 8 6 4± 17 36 ) μmol/L(P <0 0 0 1) ,喉癌患者术后 2周的血清一氧化氮含量 (91 32± 33 82 ) μmol/L ,与术前组 (12 3 74± 4 3 35 ) μmol/L比较 ,明显降低 (P <0 0 0 1) ,有淋巴结转移组 (115 2 1±2 5 4 1) μmol/L显著低于无淋巴结转移组 (12 9 4 3± 2 3 5 6 ) μmol/L(P <0 0 5 )。 结论 :喉鳞癌患者血清一氧化氮含量显著高于健康人 ,它可能在分子水平上参与了喉癌的发生发展。
Objective:To study the levels of nitric oxide (NO) in serum of 40 patients with laryngeal squamous cell carcinoma and its clinical value.Methods:The method of nitrifying ferment was used to test the level of NO and total concentration of NO - 3 and NO - 2 from patients blood.Results:(1) The volume of NO were higher in the laryngeal squamous cell carcinoma patients than that in the healthy person. The formers volume was 122 45±41 23 μmol/L, but the latters was 68 64±17 36 μmol/L( P <0 001).(2) After operation, the level of NO was lower. (3) The NO level in the lymph node metastasis group was lower than that in the non metastasis group ( P <0 05).Conclusion:The volume of NO were higher in the laryngeal squamous cell carcinoma patients than that in the healthy person; In the course of laryngeal squamous cell carcinoma, the composition and exhaust of NO were enhanced in the body of patients.
出处
《临床肿瘤学杂志》
CAS
2003年第2期88-89,共2页
Chinese Clinical Oncology
关键词
一氧化氮
喉肿瘤
鳞癌
Niric oxide
Laryngeal neoplasms
Squamous cell carcinoma
