摘要
目的 建立胚泡着床不全的实验动物模型及观测指标。方法 妊娠动物皮下注射米非司酮或利洛司酮 ,皮下注射吲哚美辛 (消炎痛 ) ,皮下注射催产素 ,给避孕药酒灌胃 ,宫腔注射纤连蛋白抗体或层粘蛋白抗体 ,皮下注射卵泡刺激素抗血清等。结果 上述方法处理后着床动物明显减少 ,着床位点数减少 ,着床率降低 ,卵巢组织上黄体数目减少 ,血清孕激素水平下降 ,绒毛膜促性腺激素水平降低。
AIM This paper reviews methods of establishing experimental animal models of implantation failure and their observing index METHORDS Pregnant animals were instilled subcutaneously mifepristone, linorpristone, indomethacin,oxytocin or antiserum to ovine FSH, given pregnancy preventing wine to stomach or intrauterine injection of antibody to fibronectin and lamin RESULT The number of imbedded,implantation site and implantation rate of mice was reduced. The number of luteam on ovary was dimimished. Serum progesterone and chorionic gonadotropin levels were significantly decreased CONCLUSION The above methods could establish animal models of implantation failure
出处
《中国药理学通报》
CAS
CSCD
北大核心
2003年第4期470-472,共3页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助课题No30 171193
关键词
动物模型
胚泡
卵着床
着床率
animal model
blastocyst
ovarum implantation
implantation rate
