摘要
为探讨补碘对缺碘机体甲状腺自身免疫的影响,采用酶联免疫分析方法测定了缺碘地区人群口服碘油前后的促甲状腺激素受体抗体(TRAb)和甲状腺刺激抗体(TSAb)水平变化。结果发现,缺碘机体补碘后的TRAb和TSAb水平均明显高于补碘前;TRAb阳性检出率增高,12个月时其阳性检出率高达24.44%。表明缺碘地区人群补碘后其自身抗体水平增高且抗体阳性率增多。提示补碘可诱导缺碘机体发生甲状腺自身免疫反应,易产生自身免疫性甲状腺疾病。
Objective To study the effects of supplying iodine on thyroid auto immunity in iodine deficiency bodies.Methods The levels of serum TRAb and TSAb w ere tested by ELISA after administrating oral iodized capsule.Results The levels of TRAb and TSAb after supplying iodine were much higher than those before supp lying iodine.The ratio of positive TRAb was increased markedly,high up to 24.4% twelve months later.Conclusions Supplying iodine for the individuals with iodine deficiency may raise the levels of autoantibodies,and increase the positive rat e.It indicates that supplying iodine for the individuals with iodine deficiency might be prone to induce thyroid autoimmune reaction,with a tendency to develop AITD.
出处
《中国地方病防治》
2002年第6期321-323,共3页
Chinese Journal of Control of Endemic Diseases
基金
山东省卫生厅资助项目(1995CA1DK1)
