摘要
目的 探讨危重患者血清细胞因子IL 6、TNF α的动态变化及临床意义。方法 采用ELISA法测定 35例危重患者IL 6及TNF α的动态变化并与正常对照组进行比较。结果 35例患者血清IL 6、TNF α于 2 4h内即显著升高 ,较正常对照组差异显著 ,以后呈波动性变化 ,于第 6天出现第 2次高峰。结论 细胞因子参与了SIRS向MODS的发生发展 ,IL 6、TNF
Objective To study the changes and clinical significance of plasma cytokines interleukin 6(IL 6) and tumor necrosis factor α(TNF α)in critically ill patients.Methods By using enzyme linked immunosorbent assay(ELISA)method,plasma IL 6?TNF α levels were measured in 35 critically ill patients,compared to healthy controls.Results Within 24 h,plasma IL 6 and TNF α levels were significantly higher in the patients compared with healthy control.Afterwards,the cytokine levels fluctuated reaching a second peak on day 6.Conclusion Cytokines IL 6 and TNF α play important roles in the development from SIRS to MODS.The chauges in their levels are probably important in the diagnosis of MODS. [
出处
《中华急诊医学杂志》
CAS
CSCD
2003年第2期109-110,共2页
Chinese Journal of Emergency Medicine
基金
西安市科委资助项目 (YG2 0 0 115 )
