摘要
目的 通过对 1992～ 2 0 0 1年从临床标本中分离的 5 186株革兰阴性 (G- )杆菌对临床抗生素的耐药性分析 ,指导临床合理选用抗生素 ,为临床抗感染治疗提供参考依据。方法 按《全国临床检验操作规程》进行。结果 连续 10年中 ,5 186株 G- 杆菌对 PIP、CAZ、CEZ、AMK、GEN5种抗生素的耐药性 ,除个别年代外 ,均呈递增趋势 ,且近两年耐药性增长尤为明显 ,以 G- 杆菌对 CEZ的平均耐药率最高占 5 2 .6% ,其次为 GEN占 43 .4% ;AMK、CAZ对 G- 杆菌的抗菌活性较好 ,平均耐药率均低于 2 0 .0 % ,可作为临床首选。另外铜绿假单胞菌对 CEZ和 GEN耐药率较高 ,PIP对大肠埃希菌耐药率较高 ,平均耐药率均超过 5 0 .0 % ,应引起临床高度重视。结论 随着抗生素的广泛使用 ,其耐药性逐渐上升 ,要加强对细菌的监测 。
OBJECTIVE To investigate clinical antibiotics resistance of the 5186 strains of Gram negative bacte ria, separated out of clinical specimen in the years of 1992 2001, make reasonal choices of the clinical antibiotics and provide reference for clinical anti infection treatment. METHODS To study in accordance with 'The National Clinical Test Regulation of Operation'. RESULTS In the past 10 years, 5 186 strains of Gram negative bacteria′s resistance towards five antibiotics, such as PIP, CAZ, CEZ, AMK and GEN have been increased by regular degrees, except in very few different years. The progressive increasement in its resistance has been very obvious in the recent two years. Gram negative bacteria′s average resistance ratio towards CEZ reaches 52%, becoming the highest; next towards GEN, reaches 43.4%. AMK and CAZ have better antibacterial activity and their average resistance ratios reach below 20%. They can be given in first priority. Moreover, the resistance ratio of Pseudomonas aeruginosa towards CEZ/GEN and PIP towards Escherichia coli is comparatively high. This needs our special attention. CONCLUSIONS Along with the widespread use of antibiotics,their resistance has also been rising. Strengthened the supervision towards bacteria and reasonable advice for medicine, should be given.
出处
《中华医院感染学杂志》
CAS
CSCD
2003年第1期71-73,共3页
Chinese Journal of Nosocomiology
