摘要
药物与肾脏的关系极为密切 ,本文主要阐述了几种抗肿瘤药物引起的肾脏损害。具有肾毒性的化疗药物包括烷化剂、抗肿瘤抗生素、抗代谢药和生物制剂 ,如顺铂、亚硝脲类、丝裂霉素、甲氨喋呤及干扰素等。其主要表现为肾小管功能障碍、肾内梗阻、急性肾衰竭 (ARF)和慢性肾衰竭、甚至溶血尿毒症综合征 ,临床表现多样化。由于多呈剂量依赖 ,正确应用药物剂量、严格掌握累积剂量、使用前后充分水化、避免同时应用几种肾毒性化疗药物以及严密检测肾功能等 。
The Kidney is adversely affected by a wide range of therapeutic agents.The renal injury caused by common antineoplastic agents including cisplatinum,mitomycin C,methotrexate,etc was described.The clinical manifestations usually include tubulointerstitial abnormalities,intrarenal obstruction,acute renal failure or chronic renal failure,even hemolytic uremia syndrome in severe cases.The nephrotoxicity is usually dose dependent in most drugs,so the dosage prescribed should be within the safe range and the total dosage should be calculated.Furthermore,the patients should be rehydrolated sufficiently before and after treatment and avoid using two or more than two nephrotoxic antineoplastic agents.The renal impairment should be closely monitored.
出处
《临床内科杂志》
CAS
北大核心
2003年第4期171-173,共3页
Journal of Clinical Internal Medicine
