摘要
目的 :在实验性大鼠心肌梗死模型上观察卡维地洛对心梗后左室功能及胶原改建的影响 .方法 :心梗后腹腔注射卡维地洛注射液 4wk或 8wk,用放免法测定血浆、心肌血管紧张素Ⅱ(AngⅡ)及血浆醛固酮 (ALD) ,动脉插管测定大鼠心功能 ,氯胺T法测定非梗塞区左室心肌羟脯氨酸含量 ,免疫组织化学法测定Ⅰ型胶原和Ⅲ型胶原含量的变化 .结果 :与心肌梗死对照组相比 ,卡维地洛可降低 8wk时的血浆、非梗死区心肌AngⅡ及血浆ALD水平 (P <0 0 5 ) ;治疗 4wk和 8wk后可明显升高 +dp/dtmax及 dp/dtmax水平 (P <0 0 5 ) ,减少非梗死区左室心肌羟脯氨酸的含量 ;降低非梗死区心肌Ⅰ型胶原和Ⅲ型胶原蛋白比值 (P <0 .0 5 ) .结论 :卡维地洛对心梗后左室功能及胶原改建可产生有益的影响 .ACEI类药物对逆转左室重塑也有有益的作用 。
AIM: To observe the effects of carvedilol injection on the left ventricular function and collagen remodeling of non-infarcted area after myocardial infarction. METHODS: Six sham operated SD rats served as controls (sham). Fifty rats with a model of myocardial infarction were randomly divided into nine groups. The rats were treated with carvedilol injection (2 mg·d -1 intraperitoneal injection) and/or captopril (2 g·L -1 drinking water). Acute myocardial infarction (AMI) group did not receive any drug treatment. The animals were sacrificed 4 weeks or 8 weeks after coronary artery ligation. The levels of plasma angiotensin Ⅱ and plasma aldosterone (by RIA) and left ventricle function (by catheter measuring ) were studied at different times. The collagen content (hydroxyproline levels) and the ratio of type Ⅰ and Ⅲ collagen (by immunohistochemical staining) of noninfarcted area were also assessed in all rats at the fourth or the eighth week. RESULTS: Compared with those of the AMI group, both carvedilol and captopril decreased the levels of plasma and myocardium angiotensin Ⅱ and plasma aldosterone at the eighth week ( P< 0 05 ) and carvedilol improved systolic and diastolic function (P<0 05). Compared with those of the sham group, both collagen content (hydroxyproline levels) and the ratio of type Ⅰ/Ⅲ collagen of noninfarcted area (including the infarct border) increased in AMI 4 and AMI 8 group (P<0.05) . The hydroxyproline levels and the ratio of type Ⅰ/Ⅲ collagen significantly decreased after carvedilol and/or captopril treatment compared with those of the AMI group at the fourth or the eighth week (P<0.05). CONCLUSION: Carvedilol can improve the cardiac function after myocardial infarction and has beneficial effects on the left ventricular collagen remodeling .
出处
《第四军医大学学报》
北大核心
2003年第6期525-528,共4页
Journal of the Fourth Military Medical University
关键词
卡维地洛
心肌梗塞
胶原
心室功能
左
carvedilol
myocardial infarction
collagen
ventricular function, left
