摘要
本文报道1例难治性皮肌炎患者使用环磷酰胺引起急性Ⅳ度胆汁淤积型肝损伤的病例。结合相关文献报道,对患者的一般情况、疾病发展和药物治疗过程等因素进行分析,探讨环磷酰胺造成肝损伤的类型、不良反应转归、作用机制和处理方法。提示在使用环磷酰胺的过程时应了解患者的肝病史、注意联合用药的肝毒性、药品累计剂量和用药监护。
One case of refractory dermatomyositis caused by acute grade IV cholestasis hepatic injury treated with cyclophosphamide was reported.Combined with relevant literature,the general situation of patients,disease development and drug treatment process were analyzed,and the types of liver injury caused by cyclophosphamide,the outcome of adverse reactions,mechanism of action and treatment methods were discussed.It is suggested that during the course of using cyclophosphamide,we should know the patient’s liver history,pay more attention to the hepatotoxicity of combined drugs,the cumulative dosage of drugs,and drug monitoring.
作者
赵方
章丽娜
王钰莹
ZHAO Fang;ZHANG Li-na;WANG Yu-ying(Departrnent of Pharmacy,Peking University International Hospital,beijing102206,china;Department of Rheumatology and Immunology,Peking University International Hospital,beijing102206,china)
出处
《临床药物治疗杂志》
2019年第8期23-25,共3页
Clinical Medication Journal
关键词
皮肌炎
环磷酰胺
肝损伤
dermatomyositis
cyclophosphamide
hepatic damage
