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hCG对人卵巢癌细胞株3AO体外生长和细胞周期的影响 被引量:1

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摘要 目的 研究人绒毛膜促性腺激素 (h CG)对卵巢癌细胞株 3AO体外生长及细胞周期的影响。方法 采用四甲基偶氮唑蓝 (MTT)比色法和流式细胞术 (FCM) ,观察卵巢癌细胞株 3AO在加入含不同浓度 h CG培养液后细胞活性和生长周期的变化。结果  1浓度为 0 .1、1μg/ ml的 h CG可刺激 3AO细胞株的生长 ,生长率分别增加到 10 9%和 12 1% ;h CG浓度为 10 μg/ ml时对细胞的生长几乎没有影响 ,浓度为 10 0 μg/ ml则抑制细胞生长。 2h CG可使 3AO细胞株 G0 / G1 期细胞比例下降 ,G2 / M期细胞比例增加 ,S期细胞变化不明显。结论  h
出处 《四川大学学报(医学版)》 CAS CSCD 北大核心 2003年第2期347-348,共2页 Journal of Sichuan University(Medical Sciences)
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  • 1[1]Wimalasena J, Meehan D, Dostal R, et al. Growth factors interact with estradiol and gonadotropins in the regulation of ovarian cancer growth and growth factor receptors. Oncol Res, 1993; 5(8):325
  • 2[2]Zheng W, Lu JJ, Luo F, et al. Ovarian epithelial tumor growth promotion by follicle-stimulating hormone and inhibition of the effect by luteinizing hormone. Gynecol Oncol, 2000; 76(1):80
  • 3[3]Fossi SL, Grenman S, Zhang FP. Ovarian cancer and gonadotropins in vitro: new evidence in favor of independence. Anticancer Res, 1999; 19(5B):4289
  • 4[4]Wimalasena J, Meehan D, Cavallo C. Human epithelial ovarian cancer cell steroid secretion and its control by gonadotropins. Gynecol Oncol, 1991; 41(1):56
  • 5[5]Parrott JA, Doraiswamy V, Kim G, et al. Expression and action of both the follicle stimulating hormone receptor and the luteinizing hormone receptor in normal ovarian surface epithelium and ovarian cancer. Mol Cell Endocrinol, 2001; 172(1-2):213
  • 6[6]Kuroda H, Mandai M, Konishi I, et al. Human chorionic gonadotropin (hCG) inhibits cisplatin-induced apoptotis in ovarian cancer cells: possible role of up-regulation of insulin-like growth factor-1 by hCG. Int J Cancer, 1998; 76(4):571
  • 7[7]Doraiswamy V, Parrott JA, Skinner MK. Expression and action of transforming growth factor alpha in normal ovarian surface epithelium and ovarian cancer. Biol Reprod, 2000; 63(3):789
  • 8[8]Kraemer S, Jaeger WH, Lang N. Growth regulation effects of gonadotropin induced steroidogenic response in human ovarian cancer. Anticancer Res, 2001; 21(3B):2005

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  • 1Ernest L. Mazzaferri.Approach to the Pregnant Patient with Thyroid Cancer[J].Clinical Endocrinology and Metabolism.2011(2)
  • 2XiaoHua Liu,Jing Shen,Rui Zhan,XingXing Wang,XiaoMing Wang,ZhiQing Zhang,Xue Leng,ZhiHua Yang,LingJia Qian.Proteomic analysis of homocysteine induced proliferation of cultured neonatal rat vascular smooth muscle cells[J].BBA - Proteins and Proteomics.2008(2)
  • 3F. Herr,N. Baal,K. Reisinger,A. Lorenz,T. McKinnon,K.T. Preissner,M. Zygmunt.hCG in the Regulation of Placental Angiogenesis. Results of an In Vitro Study[J].Placenta.2007

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