摘要
目的分析慢性阻塞性肺疾病急性期与凝血纤溶功能异常的关系。方法选取我院2016年1月-2018年1月收治的COPD患者120例纳入研究组,急性期74例,稳定期46例。另选取我院体检健康的患者120例,纳入对照组。检测所有受试者的凝血纤溶指标及肺功能。结果观察组患者PT、APTT时间较对照组延长,差异比较有统计学意义(P<0.05),FIB、D-D、LA、PLT水平高于对照组(P<0.05)。急性期患者的FIB、D-D、LA、PCO2水平低于稳定期,其中FIB、D-D、PCO2差异与稳定期组比较有统计学意义(P<0.05),LA差异与稳定期组比较无统计学意义(P>0.05)。观察组患者的FEVI、FEVI%低于对照组(P<0.05)。急性期组观察组患者的FEVI、FEVI%低于稳定期组(P<0.05)。结论慢性阻塞性肺疾病急性期凝血纤溶功能异常明显,血液处理高凝状态,严重影响肺功能。
Objective To analyze the relationship between acute chronic obstructive pulmonary disease(COPD)and abnormal coagulation&fibrinolysis.Methods 120 patients with COPD admitted in our hospital between January 2016 and February 2018 were enrolled in the study group,including 74 patients in the acute phase and 46 patients in the stable phase.Another 120 patients with physical examinations in our hospital were enrolled in the control group.Coagulation&fibrinolysis indicators and lung function were measured in all subjects.Results The PT and APTT time in the observation group were longer than those in the control group(P<0.05).The levels of FIB,D-D,LA and PLT in the observation group were significantly higher than those in the control group(P<0.05);the levels of FIB,DD,LA and PCO2 in patients of acute phase were lower than those of stable phase,where the differences of FIB,DD and PCO2 was statistically significant compared with the stable phase group(P<0.05).There was no significant difference in LA difference vs.stable phase group.(P>0.05).The FEVI and FEVI%of the observation group were significantly lower than those of the control group(P<0.05);the FEVI and FEVI%of the patients in the acute phase group were lower than those in the stable phase group(P<0.05).Conclusion The abnormal coagulation&fibrinolysis function of COPD in acute phase is very distinct with hypercoagulable blood processing,which seriously affects lung function.
作者
魏琼
周君纯
林海山
黄敦燕
梁宇亨
Wei Qiong;Zhou Junchun;Lin Haishan;Huang Dunyan;Liang Yuheng(Department of Clinical Laboratory,Fifth People's Hospital,Nanhai District,Foshan City Foshan,Guangdong 528200;Department of Pathology,the Fifth People's Hospital,Nanhai District,Foshan City Guangdong 528200)
出处
《辽宁医学杂志》
2019年第4期40-43,共4页
Medical Journal of Liaoning
关键词
慢性阻塞性肺疾病
急性期
凝血纤溶功能
异常
肺功能
高凝
Chronic obstructive pulmonary disease
Acute phase
Coagulation&fibrinolysis
Abnormalities
Pulmonary function
Hypercoagulability
