摘要
目的:探讨复方苦参注射液对中晚期乳腺癌新辅助化疗患者疗效、血清肿瘤标志物、KPS评分及不良反应的观察。方法:84例中晚期乳腺癌患者根据随机数字表法随机分为试验组42例与对照组42例。试验组剔除1例,对照组剔除3例,最终纳入80例病人。对照组仅给予化疗方案,试验组在化疗基础上联用复方苦参注射液。两组均连续观察3个疗程。比较两组患者临床疗效、血清肿瘤标记物(CEA、CA125、CA153)、KPS评分情况、中医症候积分比较及药物不良反应情况。结果:试验组有效率(60. 98%)高于对照组(48. 71%),试验组控制率(87. 8%)高于对照组(69. 2%),(P <0. 05);试验组血清CEA和CA125、CA153水平治疗后显著低于对照组(P <0. 05);试验组KPS评分提高明显高于对照组(P <0. 05);试验组白细胞减少、血小板减少、血红蛋白减少及消化道反应发生率显著低于对照组(P <0. 05)。结论:复方苦参注射液对中晚期乳腺癌新辅助化疗患者疗效明显,可降低血清CEA和CA125、CA153水平,不良反应较低,具有重要的临床价值及研究意义。
Objective:To investigate the efficacy,serum tumor markers,KPS score and toxicity of Compound Sophora flavescens injection in patients with advanced breast cancer undergoing neoadjuvant chemotherapy.Methods:84 patients with advanced breast cancer were randomly divided into experimental group(42 cases)and control group(42 cases)according to random number table method.One case in the test group and 3 cases in the control group were excluded,and 80 patients were finally included.The control group was given chemotherapy only,while the treatment group was given compound matrine injection on the basis of chemotherapy.The two groups were observed for 3 consecutive courses.The clinical efficacy,serum tumor markers(CEA,CA125,CA153),KPS score,TCM syndrome score and drug toxicity were compared between the two groups.Results:The effective rate of the experimental group(60.98%was higher than that of the control group(48.71%),the control rate of the experimental group(87.8%)was higher than that of the control group(69.2%)(P<0.05);the levels of serum CEA,CA125 and CA153 in the experimental group were significantly lower than those in the control group(P<0.05);the KPS score in the experimental group was significantly higher than that in the control group(P<0.05).The incidence of leukopenia,thrombocytopenia,hemoglobin reduction and digestive tract reaction in the experimental group was significantly lower than that in the control group(P<0.05).Conclusion:Compound Sophora flavescens injection has obvious curative effect on patients with advanced breast cancer undergoing neoadjuvant chemotherapy.It can reduce the levels of serum CEA,CA125 and CA153,with low toxicity and side effects.It has important clinical value and research significance.
作者
孙小慧
游蓉丽
李志远
赵燕
杨梦环
杨毅
SUN Xiaohui;YOU Rongli;LI Zhiyuan;ZHAO Yan;YANG Menghuan;YANG Yi(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,250014;Shandong University of Traditional Chinese Medicine;Institnte of Basic Medicine,In Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;First Clinical Medical College of Shandong University of Traditional Chinese Medicine)
出处
《辽宁中医杂志》
CAS
2019年第8期1670-1673,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
山东省自然科学基金博士基金(ZR2017BH107)
山东省保健科技协会科学技术课题(SDBJKT20180049)
关键词
复方苦参注射液
中晚期乳腺癌
新辅助化疗
临床疗效
血清肿瘤标志物
中医证候积分
不良反应
Compound Sophora Flavescens Injection
Advanced Breast Cancer
Neoadjuvant Chemotherapy
Clinical Efficacy
Serum Tumor Markers
TCM Syndrome Integral
Toxic and Side Reactions
