摘要
目的 为控制淋病的漫延 ,更加有效地利用药物资源 ,对淋球菌的药物敏感性进行了为期 4年的连续观察。方法 对每年分离的淋球菌进行 5种常用药物 (青霉素、四环素、环丙沙星、壮观霉素和头孢三嗪 )的药敏检测 ,测定淋球菌对以上药物的敏感度及耐药率。结果 壮观霉素及头孢三嗪的药物敏感度无明显改变 ,4年间未发现耐药菌株 ;环丙沙星的耐药率显著上升 ,由 1998年的 5 6.5 %上升至 2 0 0 1年的 71.4% ,PPNG和TRNG菌株在 4年内分别上升10 .0 %和 16.3 %。结论 PPNG和TRNG菌株的明显上升表明淋球菌的耐药趋势正逐渐增强 ;喹诺酮类药物的高耐药率表明该类药物已不再适宜被推荐用于治疗淋球菌感染的首选药物 ;头孢三嗪和壮观霉素尚没有耐药菌株。
Objective For slowing down the increasing speed of the disease and getting it be controlled,Gonococci isolates drug sensitivity have been monitored during the least four years from 1998 to 2001.Methods Five drugs sensitivity have been tested for GC isolated in individual year,the 5 drugs were penicillin,ciprofoxacin spectinomycin,tetracyclin and ceftriaxone.Results The ceftriazone and spectinomycin showed sensitive response in sensitive test,not any resistant isolate was developed during the four years.The resistant rate of ciprofoxacin increased to a high level,from 56.5% in 1998 to 71.4% in 2001.PPNG and TRNG growing with each passing year and raised by 10.0% and 16.3% respectively.Conclusion The high rate of PPNG and TRNG in the investigation indicated that the tendency of drug resistant in gonococci isolates was growing year by year.The ciprofoxacin showed a highly resistant in drug sensitive test for gonococci isolates.Ceftriaxone and spectinomycin showed good response in test and those two drugs were still the first choice for gonococci infection.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2003年第2期111-113,共3页
The Chinese Journal of Dermatovenereology
