摘要
目的 研究亚低温治疗对窒息后缺氧缺血性脑损伤 (HIBD)新生儿消化系统功能的影响。方法 将 5 0例重度窒息足月新生儿分为治疗组 2 3例和对照组 2 7例。两组均采用相同常规基础对症治疗。治疗组同时采用选择性头部降温方法 ,维持鼻咽温度 34± 0 .5℃ ,持续 72h ;对照组不进行亚低温治疗。检测肝功能、胆红素及临床胃肠动力学改变等指标。结果 两组肝功能异常人数比较无差异 ,生后 6 8～ 79h血清胆红素治疗组为 136± 2 7μmol/L ,对照组为 15 9±2 2 μmol/L,两组差异有显著性 (P <0 .0 5 )。结论 选择性头部降温并未加重HIBD新生儿肝脏功能损伤 ,但可能对胃肠动力存在一定影响。
Objective To study the effect of mild hypothermia on digestive system function in asphyxia newborn with hypoxic ischemic brain damage.Methods Fifty severe asphyxia newborns were submitted to study group(n=23) or control group(n=27). Head cooling therapy was chosen for study group, nasopharyngeal temperature kept at 34±0.50 ℃ for 72 hours; while control group did not receive head cooling. Liver function ,blood bilirubin and clinical gastritric motility index were monitored.Results There were no difference in the cases of abnormal liver function between control group and study group. The blood bilirubin levels in study group was 136±27 μmol/L and that in the control group was 159±22 μmol/L from 68 to 79 hours after birth; there was marked difference between the two groups (P<0.05).Conclusions Selective head cooling did not aggravate the abnormality of live function, but may be weaken the gastric motility in hypoxic ischemic brain damage newborn.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2003年第3期172-173,共2页
Journal of Applied Clinical Pediatrics
基金
"九五"国家重点科技计划 (项目编号 :96 - 90 4 - 0 6 - 0 4 )
