摘要
目的调查2型糖尿病(T2DM)与肾细胞癌(RCC)的关系,了解糖尿病是否为肾细胞癌的危险因素。方法收集肾细胞癌患者280例,依患者是否患有2型糖尿病,分为肾细胞癌组(RCC组),共122例,肾细胞癌+2型糖尿病组(RCC+T2DM),共158例。记录并分析两组患者的年龄、性别、肾细胞癌的大小及分期、糖化血清蛋白(GSP)、血清肌酐(Cr)、空腹血糖(FBG)等指标的差异。结果 (1)肾细胞癌的280例患者中,158例患有糖尿病。有2型糖尿病病史的肾细胞癌患者女性的数量(94例)相比男性(64例)更多。(2)肿瘤大小主要分布在1~4 cm范围。不同肿瘤大小的分组中,1~4 cm组,2型糖尿病合并肾细胞癌患者的GSP和FBG比单纯肾细胞癌组明显增高,差异有统计学意义(P<0.01);5~7 cm和>7 cm的两组,2型糖尿病合并肾细胞癌患者的GSP、血肌酐和FBG明显较单纯肾癌的患者明显增高,差异有统计学意义(P<0.01)。(3)肿瘤不同分期中,肾细胞癌Ⅰ期的患者比例最高(170/280),Ⅳ期所占比例最低(30/280)。在Ⅰ、Ⅱ、Ⅲ、Ⅳ期,2型糖尿病合并肾细胞癌患者的GSP、血肌酐、FBG较单纯肾细胞癌患者明显增高,差异有统计学意义(P<0.01)。结论糖尿病是肾细胞癌发生的高危因素,并与其肿瘤大小及分期相关。
Objective To find a new way for the prevention and progression of renal cell carcinoma by studying the correlation between type 2 diabetes( T2DM) and renal cell carcinoma( RCC). Methods To selected 280 patients who were diagnosed with renal cell carcinoma. Patients were divided into two groups: one group was RCC( n =122); the other group was RCC + T2DM( n = 158). Recorded and analyzed the difference between two groups of patients' age,sex,the tumor's size and stage,glycated serum protein( GSP),serum creatinine( Creatinine),Fasting plasma glucose( FBG). Results( 1) There were 280 renal cell carcinoma patients,158 cases with diabetes. Number of the women who had a history of diabetes with renal cell carcinoma( 94) were more that in than men( 64).( 2) Tumor size: Those patients' tumor size were mainly in 1- 4cm. In the size of 1- 4cm's group: RCC + T2 DM patients' GSP,FBG were significantly higher than RCC's patient,the difference had statistically significant( P < 0. 01),serum creatinine was no difference in two group; in the size of 5- 7cm and > 7cm'group: RCC + T2 DM patients' GSP,serum creatinine and FBG were significantly higher than those in RCC's patient,the differences were statistically significant( P <0. 01).( 3) Tumor stage: patients' tumor stage were mainly distributed in stageⅠ( 170 /280),the few distributed in stage Ⅳ( 30 /280). In stageⅠ,Ⅱ,Ⅲ,Ⅳperiod,RCC + T2 DM patients' GSP,serum creatinine,FBG were significantly higher than RCC's patient,the difference had statistically significant( P < 0. 01). Conclusion Diabetes is an independent prognostic factor in renal cell carcinoma and it could effect renal cell carcinoma's size and stage.
出处
《中国临床保健杂志》
CAS
2015年第1期18-21,共4页
Chinese Journal of Clinical Healthcare
关键词
糖尿病
2型
癌
肾细胞
危险因素
Diabetes mellitus,type 2
Carcinoma,renal cell
Risk factors
