摘要
目的:探讨重度子痫前期(sPE)应用天麻钩藤饮加减治疗的临床效果。方法:选取我院2017年4月—2018年2月收治的114例sPE患者,采取随机数字表法将这114例患者随机分成观察组(n=57)与对照组(n=57)。对照组予以硫酸镁治疗,观察组在此基础上联合天麻钩藤饮加减治疗。比较两组临床疗效,治疗前后微炎症指标[白介素(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)]、凝血功能指标[血管性血友病因子(vWF)、血小板α-颗粒膜蛋白(GMP-140)、凝血酶原时间(PT)]及肾功能指标[肌酐(Cr)、胱抑素C(Cys-C)、尿酸(UA)]水平变化,不良反应发生情况。结果:治疗7 d后,观察组总有效率为89.5%(51/57),较对照组[75.4%(43/57)]明显升高(P<0.05)。与治疗前对比,两组治疗后各微炎症指标(IL-6、hs-CRP、TNF-α)血清水平及血清Cr、Cys-C、UA浓度均显著降低(P<0.05);且观察组下降更显著(P<0.05)。两组治疗后血清vWF水平和外周血GMP-140含量较治疗前均显著减少(P<0.05),PT均显著延长(P<0.05);且观察组改善更显著(P<0.05)。观察组不良反应率为7.0%(4/57),与对照组[3.5%(2/57)]相比,差异无统计学意义(P>0.05)。结论:sPE应用天麻钩藤饮加减治疗可明显减轻患者症状,抑制微炎症状态,调节凝血功能,保护肾功能,疗效确切,患者耐受性好。
Objective:To explore the clinical efficacy of modified Tianma Gouteng Decoction on severe preeclampsia(sPE). Methods:The subjects of this study,114 patients with sPE admitted in our hospital from April 2017 to February 2018,were divided into observation group(n=57)and control group(n=57)on the basis of random number table. The control group was treated with magnesium sulfate,while the observation group modified Tianma Gouteng Decoction in addition to what was applied to the control group. The clinical efficacy,changes of micro-inflammatory indicators [interleukin(IL-6),hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor(TNF-α)] and coagulation function indexes [von Willebrand factor(vWF),granule membrane protein(GMP-140),prothrombin time(PT)] as well as renal function parameters [creatinine(Cr),cystatin C(Cys-C),uric acid(UA)] before and after treatment,and adverse reactions were compared between the two groups. Results:After 7 days of treatment,the overall effective rate of the observation group was 89.5%(51/57),much higher than the control group 75.4%(43/57)(P<0.05). Compared with those before treatment,the micro-inflammatory indicators(IL-6,hs-CRP,TNF-α)level and concentration of serum Cr,Cys-C,UA of both groups after treatment were significantly lower(P<0.05),and the decrease the observation group obtained in above indexes was more significant(P<0.05). After treatment both groups saw a great drop in serum vWF level and GMP-140 concentration(P<0.05),but longer PT as compared with those before treatment(P<0.05),and the improvement of the observation group was more remarkable(P<0.05). The incidence of adverse reactions of the observation group was 7.0%(4/57),seeing no big difference from 3.5%(2/57)in the control group(P>0.05). Conclusion:In treating sPE,modified Tianma Gouteng Decoction can significantly relieve the symptoms in patients,inhibit micro-inflammatory state,regulate blood coagulation function and protect renal function in patients,proves to be effective and well tolerated.
作者
赵亚宁
曹静
杨静
ZHAO Yaning;CAO Jing;YANG Jing(The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi,China)
出处
《辽宁中医药大学学报》
CAS
2019年第4期35-38,共4页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
天麻钩藤饮加减
重度子痫前期
微炎症状态
凝血功能
肾功能
modified Tianma Gouteng Decoction
severe preeclampsia
micro-inflammatory state
blood coagulation function
renal function
