摘要
目的 :评价咪唑斯汀治疗慢性荨麻疹的疗效 ,探讨IL 4在慢性荨麻疹发病中的作用。方法 :对 3 2例慢性荨麻疹患者用咪唑斯汀治疗 ,评价疗效 ,记录不良反应。同时用ELISA法检测慢性荨麻疹患者治疗前后及正常人血清IL 4的水平。结果 :治疗 1、2wk后总有效率分别为 62 .5 %、84.4% (P <0 .0 5 ) ,不良反应 3例。治疗前血清IL 4水平较正常人明显升高 (P <0 .0 1 ) ;治疗后IL 4水平下降 (P <0 .0 1 ) ,与正常人比较差异不甚明显 (P >0 .0 5 )。结论 :咪唑斯汀是一种有效、安全的治疗慢性荨麻疹的药物 ,能降低慢性荨麻疹患者血清IL
AIM: To evaluate the effect of mizolastine in patients with ch ronic urticaria and to explore the role of IL-4 in the process of chronic urtic aria. METHODS: 32 cases of chronic urticaria were treated with m izolastine, and the therapeutic effects and the side-effect were evaluated. The serum IL-4 levels were tested by ELISA. RESULTS: The total ef fective rates were 62.5 % and 84.4 % (P< 0.05 ) at the end of 1 wk and 2 wk, respectively. The side-effects were found in 3 cases ( 9 .4 %). The average levels of serum IL-4 before treatment were higher than tho se in controls (P< 0.01 ), but after treatment were not (P> 0.05 ), and before treatment were significantly higher than tho se after treatment (P< 0.01 ). CONCLUSIONS: M izolastine is an effective and safe drug in the treatment of patients with chron ic urticaria and the serum level of IL-4 decreases.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2003年第3期326-328,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
