摘要
目的 研究K ras和 p5 3基因突变与尿路上皮肿瘤的预后关系。 方法 应用聚合酶链式反应加单链多态性分析 (PCR SSCP)检测 5 2例尿路上皮肿瘤K ras和 p5 3基因突变。结果 K ras基因突变率为9 6 % (5 / 5 2 ) ,p5 3基因突变率为 4 2 3% (2 2 / 5 2 )。结论 尿路上皮肿瘤发生和发展牵涉多基因多步骤途径 ,p5 3基因突变对尿路上皮肿瘤预后有预测意义。
Objective To study K ras and p 53 gene mutation in 52 cases of urothelial tumors and the correlation to prognos is.Methods K ras and p53 gene mutation were detected with poly merse chain reaction and single stranded conformation polymorphism in 52 cases of urothelial tumors.Results K ras mutation was observed in 5 cases(9.6%) and p53 mutation,42.3%(22/52).Conclusion The pathog enesis of urothelial tumors was related to the change of various genes through m ultistep process.p53 mutation of urothelial tumors is a significant predictor fo r its prognosis.
出处
《中国基层医药》
CAS
2003年第3期202-203,共2页
Chinese Journal of Primary Medicine and Pharmacy
