期刊文献+

损毁和兴奋基底外侧杏仁核对大鼠行为活动的影响 被引量:3

Effects of destruction and excitation of basolateral amygdaloid nuclei on behavioral activity in rats
下载PDF
导出
摘要 目的 研究基底外侧杏仁核 (BLN)在行为活动调节中的作用。方法 运用立体定位技术进行核团内微量注射和核团损毁 ,通过开野实验和强迫游泳实验观察大鼠的行为活动的变化。结果 电损毁和红藻氨酸化学损毁双侧BLN后 ,自发活动减少 ,强迫游泳不动时间增加 ;而用L 谷氨酸兴奋BLN时 ,则引起相反效应 ,使自发活动增加 ,强迫游泳不动时间减少。结论 损毁BLN使行为活动减少 。 Objective To study the role of basolateral nuclei of amygdaloid body in regulating behavioral activity. Methods Sterotaxic surgery, microinjection,behavioral test were applied to investigate the behavioral activity of rats. Results Electrical lesions of bilateral BLN decreased locomotor activity and increased immobility time in the forced swimming test. Bilateral microinjection of kainic acid (KA, 0 5 μg) into BLN resulted the same effects. However,unilateral microinjection of L glutamate (L Glu, 0 1 μg) enhanced locomotor activity and shortened immobility time. Conclusion Destruction of BLN causes behavioral activity inhibiting effects;while excitation of BLN promoves behavioral activity.
出处 《安徽医科大学学报》 CAS 2003年第1期4-6,共3页 Acta Universitatis Medicinalis Anhui
基金 安徽省教育厅自然科学基金 (编号:2 0 0 2kj172 ) 安徽医科大学青年科研基金
关键词 基底外侧杏仁核 大鼠 行为活动 影响 立体定位技术 核团内微量注射 核团损毁 amygdaloid body/drug effects kainic acid/pharmacology glutamic acid/pharmacology
  • 相关文献

参考文献1

  • 1周绍慈.边缘系统与动机及情绪活动[A].见:韩济生主编.神经科学原理[C].北京:北京医科大学出版社,1999.892~902.

共引文献1

同被引文献22

  • 1陶嵘,姚树桥,赵勇,石川,张式兴.情绪应激对NOD小鼠血糖、胰岛炎及胰岛内细胞凋亡的影响[J].中国行为医学科学,2004,13(4):372-374. 被引量:2
  • 2Thomas C,Thomas E,Joshua J.Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms.J Neurosci,2003;23(33):10691~702.
  • 3Samuel D,Kazue S.Indirect projections from the suprachiasmatic nucleus to the median preoptic nucleus in rat.Brain Res,2003;987(1):100~6.
  • 4Okamura H,Abitbol M,Julien JF et al.Neurons containing messenger RNA encoding glutamate decarboxylase in rat hypothalamus demonstrated by in situ hybridization,with special emphasis on cell groups in medial preoptic area,anterior hypothalamic area and dorsomedial hypothalamic nucleus.Neuroscience,1990; 39 (3):675~99.
  • 5Meeker RB,Greenwood RS,Hayward JN.Glutamate receptors in the rat hypothalamus and pituitary.Endocrinology,1994; 134 (2):621~9.
  • 6Paxino G,Watson C eds.The rat brain in serotaxic loordinates.Sydrey:Academic Pre,1982:48~52.
  • 7Chou TC,Bjorkum AA,Gaus SE.Afferents to the ventrolateral preoptic nucleus.J Neurosci,2002;22 (3):977~90.
  • 8Schmidt K,Riese U,Li Z et al.Novel tetramic acids and pyridone alkaloids, militarinones B,C,and D,from the insect pathogenic fungus Paecilomyces militaris. J Nat Prod,2003;66(3):378~83.
  • 9Schmidt K,Li Z,Schubert B et al.Screening of entomopathogenic Deuteromycetes for activities on targets involved in degenerative diseases of the central nervous system.J Ethnopharmacol,2003;89(2-3):251~60.
  • 10Weinstock M,Poltyrev T,Bejar C et al.Effect of TV3326,a novel monoamine-oxidase cholinesterase inhibitor,in rat models of anxiety and depression. Psychopharmacology(Berl),2002;160(3):318~24.

引证文献3

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部