摘要
本文采用特异性放免法测定了不同缺氧条件下大鼠血浆内皮素含量,结果发现对照组(n=20)、单次缺氧组(n=17)、反复缺氧组雄鼠(n=11)以及雌鼠(n=9)的血浆内皮素含量分别为50.29±1.89、71.27±5.40、106.11±8.82和77.88±8.45pg/ml。单次或反复缺氧组与对照组相比差异非常显著(p<0.01或0.001)。本研究证实急性中度缺氧能引起血浆内皮素含量明显增加,而且雄性大鼠在反复缺氧以后还能进一步提高。目前已知内皮素是作用最强、持续时间最久的缩血管活性物质,体内含量过高可对心血管系统和脑微循环产生严重影响,应尽量避免。
The endothelin (ET) contents in plasma were determined with radioimmunoassay (RIA) after different hypoxia exposures. It was found that plasma ET.content in control group (n=20) , single exposure group (n=17) , male rats multiple exposure group (n =11) and female rats of multiple exposure group (n=9) were 50.29+1.89, 71. 27±5. 40, 106. 11+8.82 and 77.88+8.45pg/ml respectively. The ET content of plasma in rats of single exposure or multiple exposure group increased obviously as compared with that in rats of the control group (p<0.01 or 0.001). The results showed that both single and multiple exposures to acute moderate hyposia may lead to remarkble increase of plasma ET content in rats. And the plasma ET contents in male rats of multiple exposure group may increase further after repeated exposures to hypoxia as compared with that of single exposure group.This indicated that repeated exposures to hypoxia have accumulative damaging effect on blood vessel endotheliocyte in male rats. But there was not obvious difference between the plasma ET contents in female rats of multiple exposure group and that of single exposure group (p>0.05). This showed that the blood vessel endotheliocytes of female rats are not so sensitive to repeated hypoxia as compared with that of male rats. ET is the strongest and most long lasting vasoconstrictor substance among its kind that has already been found till today. Excessive increase of ET in the body may produce serious effect on cardiovascular system and microcirculation in the brain. During exposure to serious hypoxia in high altitude, disturbances of consciousness may develop quickly in pilots. This might be related to the rapid and massive increase of ET secretion leading to serious disorder in brain microcirculation. It should be avoided as far as possible.
出处
《航天医学与医学工程》
CAS
CSCD
1992年第4期281-285,共5页
Space Medicine & Medical Engineering
