摘要
目的 :探讨提高高原移居青年体力作业效率的药物。方法 :对海拔 3 70 0m已习服的 40名 1 8～ 2 6岁士兵随机分为 4组 ,每组 1 0人。受试者用EGM型踏车功量机作坐位踏车运动 ,初始负荷功率 2 5W ,每 3min递增 50W ,递增至 2 2 5W踏车 3min后终止。计算受试者运动心率达 1 70·min- 1 时机体所作的功 (PWC1 70 )。然后 4组受试者分别口服酪氨酸 3g、乙酰唑胺 0 .2 5g、依那普利 5mg加硝苯地平 1 0mg、安慰剂 (对照组 ) ,2·d- 1 ,连服 1 5d。在服药 1 0、1 5d、停药 1 0、2 0d时重复上述实验。结果 :服药 1 0、1 5d及停药 1 0d时 ,酪氨酸组、乙酰唑胺组、依那普利加硝苯地平组PWC1 70较服药前、停药 2 0d及对照组增高 ,P<0 .0 1或P <0 .0 5。结论 :酪氨酸、乙酰唑胺及依那普利加硝苯地平均能提高高原移居青年的体力作业效率 ,其药物的良性作用可维持 1
Objective:To study and select the medicine which could improve immigrants work efficieney at high altitude.Methods:40 healthy men who have stayed at 3 700 m altitude for 6 months were randomly divided into tyrosine group, acetazolamide group, enalapril + nifedipine group and placebo group.Four groups constantly pedaled the EGM efficiency-bicycle as load exercise (initial load 25 W, increase progressively 50 W per 3 min to 225 W) to calculate their PWC170 before taking medicine, 10 and 15 days after taking medicine , 10 and 20 days after they had stopped taking medicine.Results:As compared with control group, PWC170 significantly increased in three medicine group ( P <0.05 or P <0.01), but there was no difference between before taking medicine and 20 days after stopped taking medicine.Conclusion:There are some medicine , such as tyrosine, acetazolamide, enalapril and nifedipine, could improve the work efficiency at high altitude.
出处
《西北国防医学杂志》
CAS
2003年第2期102-103,共2页
Medical Journal of National Defending Forces in Northwest China
基金
兰州军区医药卫生科研基金资助项目 (LXH0 1- 0 6 )
