摘要
奥卡西平是一种治疗癫痫部分发作和全身强直阵挛性癫痫发作的新药。与传统抗癫痫药物相比,奥卡西平有不良反应少、自身诱导及对肝药酶的诱导作用小等优点。本文系统地介绍了奥卡西平在人体内吸收、分布、代谢和排泄的药代动力学特征,对年龄、性别、肝肾功能损伤等影响因素进行了描述,同时综述了奥卡西平及其活性代谢产物10-羟基卡马西平在动物及人体内药代动力学的立体选择性。
Oxcarbazepine is a new antiepileptic drug that has been approved for the treatment of partial onset seizures and generalized tonic-clonic seizures. Compared with traditional antiepileptic carbamazepine, oxcarbazepine shown an improved tolerability, a reduced propensity to cause liver enzyme induction and auto-induction. This article reviews the pharmacokinetics characters of absorption, distribution, metabolism and excretion of oxcarbazepine, the effects of age, gender, hepatic and renal dysfunction on pharmacokinetics, and the stereoselective pharmacokinetics of 10-hydroxycarbazepine, the active metabolite of oxcarbazepine, in animals and healthy subjects.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2003年第2期134-138,共5页
The Chinese Journal of Clinical Pharmacology
