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非注射胰岛素制剂的研究进展 被引量:2

Research Development on Non-injected Forms of Insulin
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摘要 在糖尿病治疗中,非注射胰岛素制剂替代注射胰岛素取得了较大进展。本文就非注射制剂的剂型、生物利用度和临床研究进行了综述。 Great progress has been achieved in the development of non-injected forms of insulin as altermatives to injected insulin for people with diabetes. The formulations, bioavailability and clinical research of non-injected forms of insulin are reviewed in this paper.
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2003年第2期149-150,共2页 The Chinese Journal of Clinical Pharmacology
关键词 非注射制剂 研究进展 胰岛素 生物利用度 临床研究 糖尿病 治疗 non-injected forms insulin bioavailability clinical research
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参考文献3

  • 1[1]Fishman RS, Chambers R, Shapiro DA. Insulin administrationvia the Aerodose(TM) inhaler: comparison to subcutaneously injected insulin. Diabetes 2000;49.
  • 2[2]Owens D R. Human Insulin: Clinical Pharmacological Studies in Normal Man. Lancaster: MTP Press, England. 1986. 138~ 144.
  • 3[3]Drejer k, Bech A, Hansan P. Intranasal administration of insulin with phosolipid as absorption enhancer. Diabetic Med, 1992;9:335 ~ 340.

同被引文献13

  • 1陈秋,夏永鹏,邱宗荫.胰岛素增敏剂的研究进展[J].国外医学(药学分册),2005,32(1):28-32. 被引量:8
  • 2Durra C, Curran MP. Inhaled human insulin ( Exubera ) : a review of its use in adult patients with diabetes mellitus. Drugs,2006, 66:1013-1032.
  • 3Patton JS, Bukar JG, Eldon MA. Clinical pharmacokinetics and pharmacodynamica of inhaled insulin. Clin Pharmacokinet, 2004,43 : 781-801.
  • 4Scholtz HE, Pretorius SG, Wessels DH, et al. Pharmacokinetic and glucodynamic variability: assessment of insulin glargine, NPH insulin and insulin ultralente in healthy volunteers using a euglycaemic clamp technique. Diabetologia, 2005,48 : 1988-1995.
  • 5Kapitza C, Hompesch M, Scharling B, et al. Intrasubject variability of inhaled insulin in type 1 diabetes: a comparison with subcutaneous insulin. Diabetes Technol Ther,2004, 6: 466-472.
  • 6Quattrin T, Belanger A, Bohannon NJV, et al. Efficacy and safety of inhaled insulin (Exubera) compared with subcutaneous insulin therapy in patients with type 1 diabetes, results of a 6-month,randomized, comparative trial. Diabetes Care,2004, 27:2622-2627.
  • 7邓宏明,于志清,夏宁,肖常青,李世生,黎英荣,苏宏业,梁瑜贞,覃忠.胰岛素增敏剂罗格列酮治疗2型糖尿病的临床疗效观察[J].广西医科大学学报,2000,17(5):805-807. 被引量:10
  • 8陈西敬,朱家壁,王广基,周明霞,辛芙萌,张娜,王成蹊,徐越宁.Hypoglycemic efficacy of pulmonary delivered insulin dry powder aerosol in rats[J].Acta Pharmacologica Sinica,2002,23(5):467-470. 被引量:3
  • 9张菊菊,王纪敏.口服降血糖药治疗2型糖尿病[J].新医学,2002,33(10):619-620. 被引量:5
  • 10何素婷,许激扬,陈代杰.具有α-葡糖苷酶抑制作用的抗糖尿病药物[J].工业微生物,2003,33(1):42-49. 被引量:37

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