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呼吸系统产超广谱β-内酰胺酶细菌的临床调查 被引量:25

Bacteria Producing Extended-spectrum Beta-lactmases in Respiration System:the Clinical Investigation
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摘要 目的 探讨医院感染呼吸系统革兰阴性菌产ESBLs菌株 ,监测其耐药性指导临床合理使用抗生素。方法 使用Api半自动细菌监测系统 ,药敏试验按NCCLs最新规则操作。结果 医院感染产ESBLs为 2 0 7%,依次为大肠埃希菌、肺炎克雷伯菌、其他菌也有产酶株 ,对头孢类、氨基糖苷类、磺胺类有广泛耐药 ,对喹诺酮类有较高耐药 ,对亚胺培南均敏感 ,重症病房和老年患者是高发区和高危人群。结论 检测ESBLs菌株 ,能指导临床合理用药 ,防止ESBLs病原菌暴发和流行的必要手段。 OBJECTIVE To study the production of Gram-negative bacilli extended-spectrum beta-lactmases in respiratory system nosocomial infection, detect bacterial resistance and direct the appropriate use of antibiotics in clinic. METHODS The survey is based on the analysis of a number of collected nosocomial infection cases related to ESBL-producing Gram-negative bacilli from Jan 2001 to Aug 2002. Bacterial culture was performed with routine method: drug susceptibility test Api was used according NCCLs. RESULTS In this sample, productive rate of ESBLs was 20 7%. The bacteria producing ESBLs were mainly from Escherichia coli, Klebsiella pneumoniae and other bacteria. These bacteria were all resistant to cefoxitin, aminoglycosides, sulfanilamides, quinolones, but susceptible to imipenem. ICU is a high-dangerous area, the elderly is a susceptive group. CONCLUSIONS Detection of ESBLs is good to direct appropriate use of antibiotics. It is a necessary method to prevent the outbreak of ESBLs.
出处 《中华医院感染学杂志》 CAS CSCD 2003年第4期373-374,共2页 Chinese Journal of Nosocomiology
关键词 呼吸系统 医院感染 ESBLS 耐药性 监测 超广谱Β-内酰胺酶 细菌 耐药性 Respiration system Nosocomial infection ESBLs Drug resistance Detection
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  • 1孙长贵,中华医学检验杂志,1999年,22卷,228页
  • 2Ho P L,J Antimicrob Chemother,1998年,42卷,49页
  • 3Pitout JD, Thomson KS, Hanson ND, et al. Plasmid-mediated resistance to extended-spectrum cephalosporins among Enterobacter aerogenes strains[J]. Antimicrob Agents Chemother, 1998, 42: 596-600.
  • 4Naumovski L, Quinn JP, Miyashiro D, et al. Outbreak of ceftazidime resistance due to a novel extended-spectrum beta-lactamase in isolates from cancer patients[J]. Antimicrob Agents Chemother, 1992, 36(9): 1991-1996.
  • 5National Commitee for Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing; ninth informational supplement. NCCLS document M100-S9[S]. Wayne, Pennsylvania: NCCLS, 1999. 19: 20-36.
  • 6Sanders CC, Barry AL, Washington JA, et al. Detection of extended-spectrum-β-lactamase-producing members of the family Enterobacteriaceae with the VITEK ESBL test[J]. J Clin Microbiol, 1996, 34(12): 2997-3001.
  • 7Tseng CY,Liu PY,Wu WL,et al.Comparison of detection of extended-spectrum beta-lactamases by agar dilution method,E-test ESBL screen and double disk test[J].J Microbiol Immunol Infect 1998,31(2):90-94.
  • 8Sirot D.Extended-spectrum plasmid-mediated β-lactamases[J].J Antimicrob Chemot her,1996,(SupplA):19-34.
  • 9Liu PYF,Tung JC,Ke SC,et al.Molecular epidemiology of extended-spectrum β-lactamase-producing Klebsiella pneumoniae isolates in a district hospital in Taiwan[J].Clin Microbiol,1998,36:2759-2762.
  • 10Bush K,Jacoby GA,Medeiros AA.A functional classification scheme for β-lactamases and its correlation with molecular structure[J].Antimicrob Agents Chemother,1995,39:1211-1233.

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