摘要
为探讨白血病患儿临床表现与性别、年龄、病程及类型的关系 ,对401例年龄在14岁以下的初诊白血病患儿主要临床表现与上述因素间的关系进行了Logistic回归分析。结果 :①年龄 :3～6岁及6岁以上组发生关节痛的比例是3岁以下组的3.6倍(P<0.05)与5.9倍 (P<0.01) ;3～6岁组发生突眼比例最高 ,是6岁以上组的4.6倍(P<0.05);②患病时间 :出现关节痛及贫血的比例随患病时间延长而明显增加 (P<0.05);③白血病类型 :急性非淋巴细胞白血病 (ANLL)出现关节痛、肝、脾及淋巴结肿大的比例均明显低于急性淋巴细胞白血病 (ALL ,P<0.05),而出现突眼与出血的比例则显著高于ALL(P<0.05)。提示白血病患儿关节痛及突眼等临床表现与年龄明显相关 ;出现关节痛及贫血的比例随病程延长而显著增加 ;关节痛、肝、脾及淋巴结大多见于ALL 。
To explore the relationship between children's age,gender,duration of the disease,clinical subsets and manifestation in children with acute leukemia,401children aged less than14years old were re_ trospectively analyzed with the Logistic regression models.The results showed that,①age:the main initial presentation was different with the age,the incidence of joint pain was3.6times(P<0.05)and5.9times(P<0.01)higher in the3to6years old group and over6years old group than that below3years old group respectively.The proportion of exophthalmus was the highest in3to6years old group,4.6times higher than that over6years old group(P<0.05).②The time of initial presentation:the proportion of the joint pain and anemia significantly in creased with prolongation of the disease(P<0.05).③The subsets of the acute leukemia:the proportion of arthralgia,hepato_splenomegaly and lymph node enlargement was markedly lower in children with acute nonlymphoxytic leukemia(ANLL)than that in children with acute lymphoblastic leukemia(ALL)(P<0.05),but,the proportion of exophthalmus and bleeding tendency was significantly higher than that in children with ALL(P<0.05),indicating the clinical presentations of arthralgia and exˉophthalmus etc in children with acute leukemia had close relationship to the age,and the incidence of arthalgia and anemia increased significantly with prolongation of the disease.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2003年第4期205-207,220,共4页
Journal of Clinical Pediatrics
