摘要
目的观察滋阴益气活血复方对糖尿病大鼠肾脏的形态学影响。方法采用腹腔注射链脲菌素(STZ)复制糖尿病模型。用图象分析仪、光学显微镜定量观察肾小球毛细血管厚度、系膜增生情况的病理形态学改变。结果滋阴益气活血复方能明显抑制肾小球系膜及基底膜增生程度 ,与模型组比较差异显著 (P<0 .0 5 )。结论滋阴益气活血复方对糖尿病大鼠肾小球系膜及基底膜增生有一定抑制作用。
Objective To study experimentally the effects of Yin enric hing, Qi boosting and Blood quickening Compound Formula(YQBCF) on the change s of renal s tructure at the early stage of diabetes in rats. Methods Rat models with diabetes were prepared by giving streptozocin (i.p),and hyperplasia of gl omerulus basement membrane and the thickness of mesangium were determined unde r ligh t microscope and by image analyzer.Results The hyperplasia degree of mesangium and basem ent membrane were largely inhibited among rats of treating group,significantly r educed than that in model group(P< 0.05 ).Conclusion YQBCF holds a certain degree of inhibitory effect on hyperplasia of mes angium and basement membrane of rats with diabetes.
出处
《湖南中医学院学报》
2003年第2期12-13,39,共3页
Journal of Hunan College of Traditional Chinese Medicine
基金
湖南省卫生厅资助课题 ( 960 2 0 )
