摘要
目的探讨经尿道肿瘤电切术(transurethral resection of bladder tumor,TURBt)术后辅以膀胱内灌注化疗在膀胱低度恶性潜能的乳头状尿路上皮肿瘤(bladder papillary urothelial neoplasms of low malignant potential,PUNLMP)的治疗效果。方法选取浙江省嘉兴市第一医院泌尿外科于2012年1月至2016年1月期间收治的且符合纳入标准的25例PUNLMP患者,按治疗方案不同分为单行TURBt组(A组)和TURBt术后辅以膀胱内灌注化疗组(B组),比较在两种不同治疗方案下,PUNLMP患者术后肿瘤复发的统计学差异。结果 A组8例PUNLMP患者中有3例术后复发,B组17例患者中1例术后复发,所有复发患者均再次行"TURBt术后辅以膀胱灌注化疗"方案治疗,随访期间,除A组中1例复发病例于二次TURBt术后第11个月再次复发,且病理被证实为低级别乳头状癌外,其余复发病例在二次术后随访期间无再次复发,肿瘤分级无进展。两组PUNLMP患者术后复发概率的差异具有统计学意义(P<0.05)。结论经TURBt治疗后出现复发的PUNLMP患者,存在进展为低级别乳头状癌的可能性。TURBt术后辅以膀胱内灌注化疗能够降低PUNLMP患者术后复发,改善PUNLMP患者的预后。
Objective To investigate the clinical effect by using intravesical chemotherapy after transurethral resection of bladder tumor( TURBt) on bladder papillary urothelial neoplasm of low malignant potential( PUNLMP). Methods Twenty-five cases of PUNLMP were diagnosed in our hospital between January 2012 and January 2016,which were in accordance with the inclusion criteria. All patients were divided into two groups,the patients in group A underwent TURBt and the paitients in group B were treated with intravesical chemotherapyafter the TURBt. The statistic differences of the postoperative recurrence data of these two groups were compared. Results Three cases in group A and one case in group B were found recurrence. All recurrent cases were retreated again by using intravesical chemotherapy after TURBt. In the follow-up periods,only 1 case from A group was found recurrent 11 months later after the second TURBt,which was later confirmed as low grand carcinoma. The recurrence rate between these two groups has statistical significance( P < 0. 05). Conclusions The recurrent PUNLMP after TURBt may progressed to low grand carcinoma. The intravesical chemotherapy after TURBt can decrease recurrence rate and improve the prognosis.
出处
《泌尿外科杂志（电子版）》
2016年第4期36-39,26,共5页
Journal of Urology for Clinicians(Electronic Version)
基金
浙江省医药卫生项目基金(No.2012KYB204)支持
关键词
膀胱肿瘤
低度恶性潜能
膀胱灌注
复发
Bladder tumors
Low malignant potential
Intravesical chemotherapy
recurrence
