摘要
目的综述西布曲明及其光学异构体的药理学研究概况。方法根据近年来的文献 ,介绍了西布曲明的药代动力学特点、药理作用、临床研究、不良反应、毒理研究、药物相互作用及其旋光异构体以及代谢产物旋光异构体的药理特性。结果与结论西布曲明是一种治疗肥胖症的新型药物 ,其减肥作用已被实验研究和临床研究所证实 。
Objective To review the pharmacological study on sibutramine and its optical isomers.Methods According to the documents in recent years,this paper introduced the pharmacokinetic characterization,pharmacological effects,clinical study,adverse reactions,toxicological study and drug interaction of sibutramine.The pharmacological characterizations of its optical isomers and metabolites isomers were also summarized.Results and Conclusions Sibutamine is a novel anti obesity drug,and its anti obesity effects have been demonstrated by the experimental and clinical study.It needs further study on the pharmacology of its optical isomers.
出处
《沈阳药科大学学报》
CAS
CSCD
2003年第3期222-225,共4页
Journal of Shenyang Pharmaceutical University
