摘要
目的:探究理脾复方制剂对厌食大鼠胃肠动力的影响,为临床推广应用名老中医经验方提供理论基础。方法:72只SD大鼠随机分空白A组12只、模型B组60只造模,造模成功后B组分为生理盐水C组、理脾复方制剂低、中、高剂量组(D、E、F组),每组12只,除A、B、C组外,各组给予低、中、高剂量理脾复方制剂灌胃干预治疗,每日1次,连续7天后取材,对大鼠胃排空率、与小肠推进率检测。结果:治疗前A、B组间比较,摄食量、体质量、胃排空与小肠推进率下降明显(P<0.05);治疗后各组间比较,D、E、F组促进胃排空率、小肠推进率均优于B组、C组(P<0.05),E组在增强胃排空率、小肠推进率上优于其他各组。结论:理脾复方制剂均能促进胃排空、小肠推进率,以中剂量组最佳;促进胃排空率、小肠推进率可能是理脾复方制剂治疗厌食的作用靶点之一。
Objective To explore the effect of spleen compound preparation on gastrointestinal motility in anorexia rats,and provide theoretical basis for clinical application of famous Chinese medicine practitioners.Methods Seventy-two SD rats were randomly divided into blank group A(n=12)and model group B(n=60).After successful modeling,group B was divided into normal saline group C and spleen compound preparation low,medium and high dose groups(Group D,E and F),12 in each group,a total of 6 groups.Except for groups A and B,each group was given low,medium and high dose of spleen compound preparation for intragastric intervention,once a day,and after 7 days of continuous intervention,the rats were subjected to gastric emptying and small intestine propulsion rate.Results Before treatment,the intake,body mass,gastric emptying and small intestine propulsion rate decreased significantly(P<0.05).After treatment,groups D,E and F promote gastric emptying and the small intestine propulsion rates were better than that of group B and C(P<0.05).Group E was superior to other groups in enhancing gastric emptying rate and small intestine propulsion rate.Conclusion Both spleen and compound preparations can promote gastric emptying and small intestine propulsion rate,which is best in the middle dose group.Promoting gastric emptying rate and small intestinal propulsion rate may be one of the targets of the treatment of anorexia with spleen compound preparation.
作者
谢莹
彭玉
詹伟
张嫱
刘启艳
XIE Ying;PENG Yu;ZHAN Wei;ZHANG Qiang;LIU Qiyan(Guizhou University of Traditional Chinese Medicine,Guiyang 550002,China;The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China)
出处
《中国民族民间医药》
2019年第8期29-32,共4页
Chinese Journal of Ethnomedicine and Ethnopharmacy
基金
国家自然科学基金资助项目(8166150497):理脾复方制剂对幼龄厌食大鼠脑肠肽-食欲中枢信号通路机制研究
贵州省中医药管理局中医药
民族医药资助项目(QZYY-2018-058):理脾复方制剂对Wistar厌食大鼠胃肠动力调节机制的研究
关键词
理脾复方制剂
厌食大鼠
胃肠动力
Spleen Compound Preparation
Anorexia Rats
Gastrointestinal Motility
