摘要
目的研究血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)在口腔鳞癌中的表达,探讨其与临床病理、预后的关系。方法采用SABC免疫组织化学染色方法,检测56例口腔癌中VEGF的表达和病灶微血管密度(MVD)记数,采用SPSS软件行统计分析。结果51.8%口腔癌组织VEGF呈阳性表达。VEGF表达阳性的口腔癌组织MVD显著高于VEGF表达阴性者(P<0.05)。VEGF表达与肿瘤的分化程度、淋巴结转移密切相关,而与肿瘤的临床分期无关。VEGF阴性表达的病人术后5年生存率较阳性表达者高。结论VEGF是口腔癌主要的新生血管诱导因子之一,可促进口腔癌的血管生成;VEGF可作为口腔癌预后的一个有效指标,用于识别高危转移和不良预后者。
Objective To evaluate the clinical significance of vascular endothelial growth factor(VEGF)expression in oral carcinomas.Methods Immunohistochemical staining(SABC)was used to quantify VEGF expression in specimens from56patients with oral carcinomas.SPSS statistical software was used for analysis.Results VEGF expression was ob-served in29of the patients(51.8%).The microvessel count was significantly higher(P<0.05)in the oral carcinomas with VEGF expression than in the oral carcinomas without it.In the clinicopathologic factors,lymph node metastasis(P<0.05)and differentiated degree(P<0.05)were significantly correlated with VEGF expression,but there was no significantly corre-lation between the clinicopathologic stage and VEGF positive expression.The5-year survival rate after curative surgery was better in the patients without VEGF expression(P<0.05).Conclusion This study indicates that VEGF expression is associated with angiogenesis,VEGF is one of the main angiogenic factors for oral carcinomas.Quantification of VEGF in oral tissues may provide a valuable marker for the prognosis of patients with oral carcinomas.
出处
《上海口腔医学》
CAS
CSCD
2003年第2期123-126,共4页
Shanghai Journal of Stomatology
