摘要
目的 :观察吉西他滨 (健择 ,GEM)与顺铂 (DDP)联合化疗对老年非小细胞肺癌 (NSCLC)的疗效和毒副反应。方法 :老年NSCLC 32例 ,予以GEM 1 0 0 0mg/m2 于第 1、8天静脉泵入 ,DDP 70mg/m2 第 1天静滴。 2 1天为 1周期 ,按WHO疗效及毒副反应标准评价。结果 :32例均化疗 2个周期以上 ,共化疗 1 34个周期 ,其中完全缓解 (CR) 1例 (3 .2 % ) ,部分缓解 (PR) 1 3例 (40 .6 % ) ,稳定 (SD) 1 3例 (40 .6 % ) ,进展 (PD) 5例 (1 5 .6 % ) ,有效率(RR) 4 3 .8%。主要毒副反应为骨髓抑制 ,Ⅲ～Ⅳ度血红蛋白降低周期数占 7.5 % (1 0 / 1 34) ,Ⅲ～Ⅳ度白细胞减少周期数占 1 2 .7% (1 7/ 1 34) ,Ⅲ～Ⅳ度血小板减少周期数占 2 3 .1 % (31 / 1 34)。结论 :GEM联合DDP化疗方案 ,对老年非小细胞肺癌有一定的客观肿瘤缓解率 ,毒副反应低 ,耐受性好 。
Purpose:To evaluate the effect and toxicity of gemcitabine cisplatin combination in elderly patients with advanced NSCLC.Methods:32 elderly patients were treaded with Gemcitabine 1 000 mg/m 2 on day 1,8 and DDP 70 mg/m 2 on day 1. The second treatment cycle was given on day 22.Results:Each patient was given at least 2 cycle chemotherapy. All together 134 cycles were given. The overall response rate (the completed response plus partial response) was 43.8%. The main toxicity was bone marrow depression. The proportion of WHO grade 3 4 hemoglobin, leukocyte and thrombocyte decrease cycles was 7.5%, 12.7%, 23.1%, respectively.Conclusions:Gemcitabine cisplatin combination is effective and well tolerated for elderly patients with NSCLC.
出处
《中国癌症杂志》
CAS
CSCD
2003年第2期170-171,共2页
China Oncology
