摘要
以盐酸氢吗啡酮为模型药物 ,制备了 6种不同类型的骨架片 ,研究了工艺参数对骨架片释放行为的影响。结果表明 :(1) HPMC与十八醇或 EC合用能明显减小压片压力对释放的影响 ;(2 )对于 HPMC亲水凝胶骨架片 ,用含1% HPMC K4 M的 5 0 %乙醇湿法制粒的效果与粉末直接压片相当 ;对于 HPMC-十八醇混合骨架片 ,湿法制粒的释药快于熔融制粒法 ;(3) HPMC-十八醇混合骨架片释放受片径或 (和 )片重改变的影响小于 HPMC- CMC- Na-十八醇混合骨架片 ;(4)包薄膜衣、制粒大小及工艺放大对 HPMC-十八醇混合骨架片的释放基本无影响。
The effects of preparation parameters on the release of hydromorphone hydrochloride from six various of matrices were investigated. The results showed that: (1) combined use of HPMC with octadecanol or EC could remarkably decrease the effect of compression force on drug release; (2) drug release from HPMC hydrocolloid matrices prepared by wet granulation method with 1% HPMC K4M in 50% ethanol was comparable to those prepared by direct powder compression procedure; drug release from combined HPMC octadecanol matrices prepared by wet granulation method was faster than those prepared by melt granulation method; (3) drug release from combined HPMC octadecanol matrices varied with tablet diameter or/and weight less than those from combined HPMC CMCNa octadecanol matrices; (4) film coating, granule size and scale up of process had little effect on drug release from combined HPMC octadecanol matrices.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2003年第5期226-229,共4页
Chinese Journal of Pharmaceuticals
关键词
骨架片
盐酸氢吗啡酮
体外释药
matrices
hydromorphone hydrochloride
in vitro release
