摘要
僵蚕提取液在体内、外均有较强的抗凝作用。在体外对凝血酶时间、凝血酶原时间和白陶土部分凝血活酶时间的延长作用,每克生药分别相当于1.08、13.47和14.50单位肝素,提示其抗凝血因子Xa的活性远高于抗凝血酶活性,其性质更接近低分子量肝素。该活性的表达不依赖于抗凝血酶Ⅱ;其成分不属糖、甙或生物大碱类,但具体成分未明。
The extract parepared from Batrytis bassiana Bals. Presented anticoagulant activity both in vitro and in vivo. The effects of the extract on prolonging thrombin time, prothrombin time and kaoline partial thromboplastin time in vitro were compat- ible to those of 1.08, 13. 47 and 14. 5 units of heparin, suggesting a high ratio of anti-Xa to antithrombin avtivites. The anticoagulant activity expression of the ex- tract was independent of antithrombin-Ⅲ. The component related to the anticoagulant is not clear, though the possibility, of belonging to carbohydrates, glycodides or a- lkaloides has been excluded.
出处
《湖南中医学院学报》
1992年第3期37-40,共4页
Journal of Hunan College of Traditional Chinese Medicine
关键词
僵蚕
抗凝血酶
Batrytis bassiana BaIs./analysis
antithrombin/analysis
heparin
thrombin time
prothrombin time
kaoline
partial thromboplastin time.
