期刊文献+

齐酞酸钠对免疫性肝损伤模型小鼠的保护作用 被引量:5

The Protective Effect of OAPES on Mice Model of Immune Hepatic Injury Induced by BCG Plus LPS
下载PDF
导出
摘要 目的 观察齐酞酸钠 (Oleanolicand 3β-phthalicmonoesterdisodiumsalt,OAPES)对BCG(卡介苗 )加LPS(脂多糖 )诱导的小鼠免疫性肝损伤的保护作用。方法 采用卡介苗 (BCG)加脂多糖 (LPS)诱导小鼠免疫性肝损伤 ,通过检测小鼠的胸腺、肝脏、脾脏指数以及血清谷丙转氨酶 (ALT)、谷草转氨酶 (AST)活性来研究OAPES的保肝功能。结果 造模组小鼠与正常对照组相比 ,胸腺指数明显减小 ,肝脏指数及脾脏指数明显增大 ,血清ALT及AST活性显著增高 ;给药组中、小剂量组 (10 0、5 0mg·kg-1)显著降低模型小鼠血清ALT及AST活性 ,大 (2 0 0mg·kg-1)、中剂量组可显著增大胸腺指数。结论 本实验成功地复制了BCG加LPS诱导小鼠产生免疫性肝炎的模型 ; Aim To study the protective action of Oleanolic and 3β-phthalic monoester disodiumsalt (OAPES) on the hepatic injury mice model induced by BCG plus LPS.Methods The injury of mice liver was induced by BCG plus LPS.The protective effects of OAPES on liver were studied by detecting the index of thymus,liver,spleen and the serum ALT and AST.Results The results showed that:(1) The thymic index of model mice reduced obviously,while the splenic and hepatic index increased greatly.Furthermore,the serum ALT and AST were significantly increased than those in the normal group mice.(2)The serum ALT and AST of mice in the experiment group treated with median and low dose OAPES (100 and 50mg·kg -1 ) decreased significantly after 6 days,while the thymic index of those treated with high (200mg·kg -1 ) and median dose OAPES were obviously higher than those in the model group.Conclusions We have successfully established the mice model of immune hepatic injury induced by BCG plus LPS.The results indicate that OAPES has significant protective effects on this injury.
出处 《解放军药学学报》 CAS 2003年第2期109-111,共3页 Pharmaceutical Journal of Chinese People's Liberation Army
关键词 齐酞酸钠 免疫性肝损伤 小鼠 动物模型 卡介苗 脂多糖 保护作用 免疫性肝炎 Oleanolic and 3β-phthalic monoester disodiumsalt Immune hepatic injury BCG LPS
  • 相关文献

参考文献3

二级参考文献9

  • 1徐强,王蓉,徐丽华.迟发型变态反应机制致肝损伤的动物模型的建立[J].中国免疫学杂志,1993,9(5):287-290. 被引量:9
  • 2张乐之,中药药理与临床,1992年,8卷,2期,24页
  • 3李仪奎,中药药理实验方法学,1991年,460页
  • 4孙荫,实用临床检验手册,1990年,178,190页
  • 5刘亚平,中药药理与临床,1987年,3卷,1期,34页
  • 6马学惠,药学学报,1982年,17卷,2期,93页
  • 7团体著者,中草药通讯,1977年,4期,32页
  • 8孙燕,袁瑞荣,吴迺居,李惟敏,胡青龙,邱跃,赵泰.齐墩果酸的促免疫作用[J]中国临床药理学杂志,1988(01).
  • 9孙悦平,吕式琪.齐墩果酸对小鼠肝脏的毒性作用[J]北京第二医学院学报,1983(04).

共引文献38

同被引文献81

引证文献5

二级引证文献111

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部