摘要
目的本文介绍一种培养心脏细胞自发搏动的复杂节律—整数倍节律 ,并探讨其产生机理和可能生理意义。方法乳鼠心肌细胞离体培养 ,利用光密度检测系统记录细胞自发性搏动节律并进行分析 ;利用理论模型数值仿真分析实验现象的发生机理。结果实验中发现整数倍节律 ,其特征是周期 1节律的基础上有停搏现象 ,停搏间期大约是正常间期的整数倍 ;利用心肌细胞理论模型进行理论分析 ,发现了类似节律并证明该节律是随机自共振效应引起的。该类节律与窦性停搏现象和某些窦房阻滞时心脏异常的节律表现类似。结论随机自共振机理是引起整数倍节律的原因 。
Objective To introduce the characteristics of the integer multiple rhythm of cultured cardiac myocytes and to explore the cause of its generation. Method Spontaneous beating rhythms of cultured cardiac myocytes were observed with photometry system and stochastic Chay model was used to simulate the experimental results. Result Integer multiple rhythm was observed in the experiment. This kind of rhythm is similar to phenomena of sinus arrest. The integer multiple rhythm similar to that of the experiments was simulated in stochastic Chay model, and was demonstrated to be induced by the mechanism of autonomous stochastic resonance. Conclusion The integer multiple rhythm observed in the experiment might be generated via the effect of autonomous stochastic resonance.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2003年第2期142-144,共3页
Space Medicine & Medical Engineering
基金
总装备部实验技术重点项目 (0 110 0 30 1和 0 110 330 2 )资助
