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类风湿性关节炎超声评分与DAS-28评分的相关性研究 被引量:7

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摘要 目的:探讨类风湿性关节炎(rheumatoid arthritis,RA)的超声评分与DAS-28评分相关性。方法:对83例RA患者病情活动性进行DAS-28评分,应用高频超声对DAS-28评分对应关节的滑膜增生、滑膜炎能量多普勒(power Doppler,PD)及骨侵蚀情况进行超声评分,各受累关节的评分相加为超声最终得分;常规检测患者类风湿因子(RF)、血沉(ESR)、C反应蛋白(CRP)、抗环瓜氨酸肽抗体(A-CCP),分析超声总评分与DAS-28评分及实验室指标的相关性。结果:超声总评分与DAS-28评分呈正相关(r=0.434,P <0.01),超声总评分、DAS-28评分与ESR呈正相关(P均<0.05);DAS-28评分与滑膜增生、滑膜炎PD评分及骨侵蚀评分均有相关性:与滑膜增生及滑膜炎PD评分的相关性高于骨侵蚀。滑膜增生、滑膜炎PD评分与ESR、CRP有相关性,骨侵蚀评分与ESR、CRP无相关性,其中滑膜炎PD评分与ESR相关性最高(r=0.303,P <0.01);滑膜增生、滑膜炎PD及骨侵蚀评分与RFA-CCP均无相关性。结论:超声评分与DAS-28评分呈正相关,超声评分法可以客观评估类风湿关节炎的活动性,联合应用DAS-28评分及超声评分可较为客观地反映RA的临床活动性。
出处 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2019年第1期90-93,共4页 Journal of Nanjing Medical University(Natural Sciences)
基金 无锡市卫计委面上指令性项目(ML201316)
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