摘要
目的:对非瓣膜性房颤病人引起房颤的相关因素进行相关分析,并探讨在低抗凝强度下华法林预防脑血管栓塞的疗效。方法:观察58例非瓣膜持续性房颤病人C反应蛋白(CRP)、氨基酸末端脑钠肽前体(NTproBNP)水平、心房、心室大小、射血分数等相关指标,并将其分为对照组阿司匹林组(30例)及实验组华法林组(28例),华法林组调整华法林剂量使国际标准化比值(INR)1.6~2.5之间,随访观察病人缺血性脑卒中、出血事件的发生情况。结果:左心房内径是影响CRP、NT-proBNP水平(P<0.05)的因素。阿司匹林组发生缺血性脑卒中4例,华法林组0例,两组有统计学意义(P<0.05),阿司匹林组发生出血事件0例,华法林组发生出血事件1例,两组在统计学上无差异性(P>0.05)。结论:CRP、NT-proBNP是影响房颤的相关因素,可能参与了房颤的发生发展。口服华法林的病人,将抗凝强度定在INR1.6~2.5,能有效预防血栓栓塞事件的发生,同时并不增加出血的风险。
Objective: Analysis the nonvalvular atrial fibrillation patients with continueing fibrillation and it's relevant factors. Exploring the low-intensity warfarin anticoagulation in prevent thromboembolic situation. Methods: Observed the relevant indicators of C-reactive protein( CRP) 、N-terminal fragment pro-brain natriuretic peptide( NT-proBNP) level、atrium、ventricular inside diameter and left ventricular ejection fraction. of 58 nonvalvular atrial fibrillation patients. All the patients were divided into two groups: aspirin group( n = 30) and warfarin group( n = 28). warfarin group patients had warfarin and adjust international normalized ratio( INR) between1. 6 ~ 2. 5. Observed the effect of warfarin in preventing ischemic stroke and bleeding occurs. Results: The left atrial inside diameter was the influence factor of the levels of CRP、NT-proBNP levels( P < 0. 05). 4 cases in Aspirin group occurred ischemic stroke,and warfarin group occurred no patients. The two group was statistically significant( P < 0. 05). Aspirin group occurred no cases with bleeding events,1 case in warfarin group occurred bleeding events,the two groups were no statistically significant( P > 0. 05). Conclusion: CRP and NT-proBNP was the affect factors of non-valvular atrial fibrillation,may be involved in the occurrence and continuance of atrial fibrillation. Oral warfarin patients,anticoagulation intensity set at INR1. 6 ~ 2. 5,can be effective in preventing thromboembolic events,does not increase the risk of bleeding.
出处
《内蒙古医科大学学报》
2014年第S1期1-6,共6页
Journal of Inner Mongolia Medical University
基金
国家"十五"攻关课题(2001ABA703B16)
内蒙古医科大学附属医院重大课题(2006FYZD04)
关键词
心房颤动
华法林
C反应蛋白
氨基酸末端脑钠肽前体
Atrial Fibrillation
Warfrin
C-reactive protein
N-terminal fragment pro-brain natriuretic peptide
